{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:57:26Z","timestamp":1785427046437,"version":"3.56.0"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Innovation capability strong foundation plan of Xi'an City","award":["22YXYJ0117"],"award-info":[{"award-number":["22YXYJ0117"]}]},{"DOI":"10.13039\/501100015401","name":"Key Research and Development Program of Shaanxi","doi-asserted-by":"publisher","award":["2023-YBSF-320"],"award-info":[{"award-number":["2023-YBSF-320"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"name":"2024 Shaanxi Provincial Health high-level talent (team) cultivation plan-Young Talent Project"},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["xzy012024146"],"award-info":[{"award-number":["xzy012024146"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170114"],"award-info":[{"award-number":["32170114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31770152"],"award-info":[{"award-number":["31770152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shaanxi Fundamental Science Research Project for Chemistry & Biology","award":["22JHZ008"],"award-info":[{"award-number":["22JHZ008"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2025,6,17]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      The vaginal microbiota plays a crucial role in vaginal health and pregnancy outcomes. However, the influence of maternal characteristics, especially age, on the relationship between the vaginal microbiota and preterm birth is poorly understood. This study quantifies the effects of race, maternal age, and gestational age on vaginal microbiota composition using publicly available 16S rRNA sequencing data. Our results demonstrate stronger associations between preterm birth and a less optimal vaginal microbiota in White and Asian women compared to Black or African American women. The microbiota difference between preterm and term births was more pronounced in older reproductive-age women, with\n                      <jats:italic toggle=\"yes\">Lactobacillus<\/jats:italic>\n                      species increasing with age only in term births. Additionally, lower alpha diversity was observed in term pregnancies compared to preterm during both early and late pregnancy, particularly in women aged above 25 years. These findings highlight the mediating role of age in the relationship between the vaginal microbiota and preterm birth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>IMPORTANCE<\/jats:title>\n                    <jats:p>The findings from this study have potential clinical implications for managing preterm birth (PTB) risks. By identifying maternal age as a key factor affecting the vaginal microbiota, healthcare providers can develop age-specific preventive strategies. Interventions aimed at optimizing the vaginal microbiota in older reproductive-age women may be more effective than in younger women for reducing PTB risk. These insights could inform personalized clinical approaches, ultimately improving pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/msystems.00149-25","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T09:00:21Z","timestamp":1747731621000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Role of age in mediating the association between the vaginal microbiota and preterm birth"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6147-9638","authenticated-orcid":false,"given":"Yun","family":"Xie","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00wydr975","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Laboratory Medicine, Northwest Women\u2019s and Children\u2019s Hospital","place":["Xi'an, 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