{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T19:19:38Z","timestamp":1792351178521,"version":"4.4.0"},"reference-count":62,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18gm0710005"],"award-info":[{"award-number":["JP18gm0710005"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18H04068"],"award-info":[{"award-number":["JP18H04068"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18H05387"],"award-info":[{"award-number":["JP18H05387"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19H03862"],"award-info":[{"award-number":["JP19H03862"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K17281"],"award-info":[{"award-number":["JP18K17281"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"HHS | NIH | National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE012505"],"award-info":[{"award-number":["DE012505"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"HHS | NIH | National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE023193"],"award-info":[{"award-number":["DE023193"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"HHS | NIH | National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE011111"],"award-info":[{"award-number":["DE011111"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2022,8,30]]},"abstract":"<jats:p>\n                    Periodontitis is caused by a pathogenic shift in subgingival biofilm ecosystems, which is accompanied by alterations in microbiome composition and function, including changes in the metabolic activity of the biofilm, which comprises multiple commensals and pathogens. While\n                    <jats:named-content content-type=\"genus-species\">Fusobacterium nucleatum<\/jats:named-content>\n                    is a common constituent of the supra- and subgingival biofilms, its metabolic integration within polymicrobial communities and the impact on periodontal pathogenesis are poorly understood.\n                  <\/jats:p>","DOI":"10.1128\/msystems.00170-22","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T09:00:24Z","timestamp":1658221224000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":132,"title":["Fusobacterium nucleatum Metabolically Integrates Commensals and Pathogens in Oral Biofilms"],"prefix":"10.1128","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9733-6886","authenticated-orcid":true,"given":"Akito","family":"Sakanaka","sequence":"first","affiliation":[{"name":"Department of Preventive Dentistry, Graduate School of Dentistry, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masae","family":"Kuboniwa","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Graduate School of Dentistry, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4699-6590","authenticated-orcid":true,"given":"Shuichi","family":"Shimma","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar A.","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Graduate School of Dentistry, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Mayumi","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Graduate School of Dentistry, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3147-5039","authenticated-orcid":true,"given":"Richard J.","family":"Lamont","sequence":"additional","affiliation":[{"name":"Department of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichiro","family":"Fukusaki","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Graduate School of Dentistry, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0006"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0089-x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.11.004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01012-14"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0004-5"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07707.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12170"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-014-4067-3"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-017-0021-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-020-00865-y"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00321-19"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1994.tb00019.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2012.174"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0129-6"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2381"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-148-2-467"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.9.1.55"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01945"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.644401"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.204"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00379-18"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00269-18"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.10.6318"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01249.x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1992.tb00592.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302x.1994.tb00062.x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00124"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1039\/c8np00009c"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-020-01353-4"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07946-9"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/foods8010017"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101219"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2012.54"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.39733"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2114909119"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.TM118.005670"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-018-1339-7"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26009-0"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.307835"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.188.7.2355-2363.2006"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.163154"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.012"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00265-16"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00664-17"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03835.x"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-019-0360-9"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep38993"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509341967"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516661142"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep42818"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519866440"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.09.008"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.172.10.5714-5723.1990"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.GPP3-0042-2018"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.3920\/BM2015.0132"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12566"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.2116\/analsci.18SCN01"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1996.tb08325.x"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.9.5794-5804.2001"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110664"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-148-1-257"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0902-0055.2004.00135.x"}],"container-title":["mSystems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.00170-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.00170-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T15:01:13Z","timestamp":1723388473000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msystems.00170-22"}},"subtitle":[],"editor":[{"given":"Heather D.","family":"Bean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,30]]},"references-count":62,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8,30]]}},"alternative-id":["10.1128\/msystems.00170-22"],"URL":"https:\/\/doi.org\/10.1128\/msystems.00170-22","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.06.23.449328","asserted-by":"object"}]},"ISSN":["2379-5077"],"issn-type":[{"value":"2379-5077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,30]]},"assertion":[{"value":"2022-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00170-22"}}