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The genetic diversity of\n            <jats:named-content content-type=\"genus-species\">B. anthracis<\/jats:named-content>\n            is known to be low compared with that of\n            <jats:named-content content-type=\"genus-species\">Bacillus<\/jats:named-content>\n            species. In this study, we performed whole-genome sequencing of Zambian isolates of\n            <jats:named-content content-type=\"genus-species\">B. anthracis<\/jats:named-content>\n            to understand the genetic diversity between closely related strains. Comparison of genomic sequences revealed that closely related strains were separated into three groups based on single nucleotide polymorphisms distributed throughout the genome. A large genomic deletion was detected in the region containing a bacitracin resistance gene cluster flanked by rRNA operons, resulting in the loss of bacitracin resistance. The structure of the deleted region, which was also conserved among species of the\n            <jats:named-content content-type=\"genus-species\">Bacillus cereus<\/jats:named-content>\n            group, has the potential for both deletion and amplification and thus might be enabling the species to flexibly control the level of bacitracin resistance for adaptive evolution.\n          <\/jats:p>","DOI":"10.1128\/msystems.00182-18","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T12:59:24Z","timestamp":1540817964000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Loss of Bacitracin Resistance Due to a Large Genomic Deletion among\n            <i>Bacillus anthracis<\/i>\n            Strains"],"prefix":"10.1128","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4710-1389","authenticated-orcid":false,"given":"Yoshikazu","family":"Furuta","sequence":"first","affiliation":[{"name":"Division of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Harima","sequence":"additional","affiliation":[{"name":"Hokudai Center for Zoonosis Control in Zambia, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-616X","authenticated-orcid":false,"given":"Fumito","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Ohnishi","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Osaki","sequence":"additional","affiliation":[{"name":"TOMY Digital Biology Co., Ltd., Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohito","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Hokudai Center for Zoonosis Control in Zambia, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Squarre","sequence":"additional","affiliation":[{"name":"Department of National Parks and Wildlife, Chilanga, Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard Mudenda","family":"Hang'ombe","sequence":"additional","affiliation":[{"name":"Department of Para-clinical Studies, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Higashi","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.1999.00903.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.55.1.647"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-091014-104523"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.10.3472-3477.1991"},{"key":"e_1_3_2_6_2","first-page":"15","article-title":"Ecology and epidemiology of anthrax in cattle and humans in Zambia","volume":"54","author":"Siamudaala VM","year":"2006","unstructured":"Siamudaala VM, Bwalya JM, Munang'andu HM, Sinyangwe PG, Banda F, Mweene AS, Takada A, Kida H. 2006. 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