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We determined that this pathogen initiates a transcriptional program that prioritizes replenishment of nutrient stores over replication, possibly in preparation for rapid growth once optimal iron levels are restored. Transcription of genes for biosynthesis of metabolic precursors was generally upregulated, while those involved in multiple steps of translation were downregulated. We also observed an increase in transcription of genes involved in DNA repair and neutralizing oxidative stress, indicating that\n                    <jats:italic>Chlamydia<\/jats:italic>\n                    employs an \u201call-or-nothing\u201d strategy. Its small genome limits its ability to tailor a specific response to a particular stress. Therefore, the \u201call-or-nothing\u201d strategy may be the most efficient way of surviving within the host, where the pathogen likely encounters multiple simultaneous immunological and nutritional insults.\n                  <\/jats:p>","DOI":"10.1128\/msystems.00184-17","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T08:00:58Z","timestamp":1518422458000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Genomewide Transcriptional Responses of Iron-Starved Chlamydia trachomatis Reveal Prioritization of Metabolic Precursor Synthesis over Protein Translation"],"prefix":"10.1128","volume":"3","author":[{"given":"Amanda J.","family":"Brinkworth","sequence":"first","affiliation":[{"name":"School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Wildung","sequence":"additional","affiliation":[{"name":"School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA"},{"name":"Laboratory of Biotechnology and Bioanalysis, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5708-5493","authenticated-orcid":false,"given":"Rey A.","family":"Carabeo","sequence":"additional","affiliation":[{"name":"School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Sexually transmitted disease surveillance 2015","author":"CDC","year":"2016","unstructured":"CDC. 2016. 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