{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:48:05Z","timestamp":1787237285448,"version":"build-2736575974"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"NASA Research Announcement Research Opportunities in Space and Earth Science"},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA033572"],"award-info":[{"award-number":["P30CA033572"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006196","name":"NASA | Jet Propulsion Laboratory","doi-asserted-by":"publisher","award":["1576895"],"award-info":[{"award-number":["1576895"]}],"id":[{"id":"10.13039\/100006196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2019,8,27]]},"abstract":"<jats:p>\n                    Spore-forming bacteria are well known for their resistance to harsh environments and are of concern for spreading contamination to extraterrestrial bodies during future life detection missions.\n                    <jats:named-content content-type=\"genus-species\">Bacillus pumilus<\/jats:named-content>\n                    has been regularly isolated from spacecraft-associated surfaces and exhibited unusual resistance to ultraviolet light and other sterilization techniques. A better understanding of the mechanisms of microbial survival and enhanced resistance is essential for developing novel disinfection protocols for the purpose of planetary protection. While genomic analyses did not reveal the unique characteristics that explain elevated UV resistance of space-exposed\n                    <jats:italic>B. pumilus<\/jats:italic>\n                    , the proteomics study presented here provided intriguing insight on key metabolic changes. The observed proteomics aberrations reveal a complex biological phenomenon that plays a role in bacterial survival and adaptation under long-term exposure to outer space. This adaptive ability of microorganisms needs to be considered by those tasked with eliminating forward contamination.\n                  <\/jats:p>","DOI":"10.1128\/msystems.00195-19","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T10:21:07Z","timestamp":1560162067000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Alteration of Proteomes in First-Generation Cultures of Bacillus pumilus Spores Exposed to Outer Space"],"prefix":"10.1128","volume":"4","author":[{"given":"Abby J.","family":"Chiang","sequence":"first","affiliation":[{"name":"Department of Molecular Imaging and Therapy, Beckman Research Institute of City of Hope, Duarte, California, USA"},{"name":"Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh 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