{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:20:22Z","timestamp":1791958822379,"version":"4.3.4"},"reference-count":58,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["intramural funding"],"award-info":[{"award-number":["intramural funding"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2022,8,30]]},"abstract":"<jats:p>\n            AdeABC is an important efflux pump in\n            <jats:named-content content-type=\"genus-species\">A. baumannii<\/jats:named-content>\n            that plays a role in resistance toward different antibiotics including the \u201clast resort\u201d antibiotic, carbapenem. This pump is regulated by a two-component system, AdeRS.\n          <\/jats:p>","DOI":"10.1128\/msystems.00217-22","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T12:30:14Z","timestamp":1655987414000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Differential Binding of Carbapenems with the AdeABC Efflux Pump and Modulation of the Expression of AdeB Linked to Novel Mutations within Two-Component System AdeRS in Carbapenem-Resistant Acinetobacter baumannii"],"prefix":"10.1128","volume":"7","author":[{"given":"Subhasree","family":"Roy","sequence":"first","affiliation":[{"name":"Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Junghare","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Bioengineering, Indian Institute of Technology Roorkee (IITR), Roorkee, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanta","family":"Dutta","sequence":"additional","affiliation":[{"name":"Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3074-1534","authenticated-orcid":false,"given":"Saugata","family":"Hazra","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Bioengineering, Indian Institute of Technology Roorkee (IITR), Roorkee, Uttarakhand, India"},{"name":"Centre for Nanotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7811-7140","authenticated-orcid":true,"given":"Sulagna","family":"Basu","sequence":"additional","affiliation":[{"name":"Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"WHO. 2017. Global Antimicrobial Resistance Surveillance System (GLASS) report: early implementation 2016\u20132017. Geneva Switzerland: World Health Organization."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00310-16"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161213804070285"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ram.2017.10.006"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2012.06.001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.masthead.30-1"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2247-y"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4073-5"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-019-0537-z"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-014-2365-8"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.20546\/ijcmas.2018.702.145"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15010153"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.108724"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9129083"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01126"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(16)30148-6"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1179\/2046905513Y.0000000072"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.71814"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0048-6"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000069"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2019.100549"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01295-19"},{"key":"e_1_3_2_24_2","first-page":"822","article-title":"Disruption of adeB gene has a greater effect on resistance to meropenems than adeA gene in Acinetobacter spp. isolated from University Malaya Medical Centre","volume":"50","author":"Wong EW","year":"2009","unstructured":"Wong EW, Yusof MY, Mansor MB, Anbazhagan D, Ong SY, Sekaran SD. 2009. Disruption of adeB gene has a greater effect on resistance to meropenems than adeA gene in Acinetobacter spp. isolated from University Malaya Medical Centre. Singapore Med J 50:822\u2013826.","journal-title":"Singapore Med J"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.19.6804-6815.2005"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525143113"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03690-20"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.9.3298-3304.2004"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3511-0"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S151423"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2016.01.018"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_644_16"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/13102818.2015.1135082"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.06.012"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky083"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw002"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02556-12"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02413-15"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2015.11.010"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083137"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1218348109"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/09687680802552257"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09395"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.05.038"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00314-16"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05076"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.08.037"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.12.008"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2005.06.006"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl493"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.3.1043-1046.2004"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr168"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrp.2011.11.040"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060666"},{"key":"e_1_3_2_55_2","unstructured":"Clinical and Laboratory Standards Institute. 2021. Performance standards for antimicrobial susceptibility testing 31st ed. CLSI Malvern PA."},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl081"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01388-10"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00730-13"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.602724"}],"container-title":["mSystems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.00217-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.00217-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T19:04:31Z","timestamp":1723403071000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msystems.00217-22"}},"subtitle":[],"editor":[{"given":"Christopher W.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,30]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8,30]]}},"alternative-id":["10.1128\/msystems.00217-22"],"URL":"https:\/\/doi.org\/10.1128\/msystems.00217-22","relation":{},"ISSN":["2379-5077"],"issn-type":[{"value":"2379-5077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,30]]},"assertion":[{"value":"2022-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00217-22"}}