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A recombinant\n                    <jats:named-content content-type=\"genus-species\">Bacillus subtilis<\/jats:named-content>\n                    expressing a fusion protein CotB-HcGAPDH on its spore\u2019s surface induced strong Th1 immune response in a murine model. The same probiotic recombinant, upon only one oral application, protected sheep against\n                    <jats:italic>H. contortus<\/jats:italic>\n                    infection by reducing egg shedding and decreasing adult worm loads of the parasite and increasing body weight gain of infected sheep. 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