{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T13:49:58Z","timestamp":1793886598993,"version":"4.8.0"},"reference-count":106,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"The Sanming Project of Medicine in Shenzhen Nanshan","award":["SZSM202103007"],"award-info":[{"award-number":["SZSM202103007"]}]},{"name":"Major Program of Shenzhen Nanshan","award":["NSZD2023046"],"award-info":[{"award-number":["NSZD2023046"]}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81871026"],"award-info":[{"award-number":["81871026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32371029"],"award-info":[{"award-number":["32371029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions","award":["2023SHIBS0002"],"award-info":[{"award-number":["2023SHIBS0002"]}]},{"name":"Shenzhen Medical Research Fund","award":["B2301001"],"award-info":[{"award-number":["B2301001"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2024,6,18]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by social communication deficiencies and stereotypic behaviors influenced by hereditary and\/or environmental risk factors. There are currently no approved medications for treating the core symptoms of ASD. Human fecal microbiota transplantation (FMT) has emerged as a potential intervention to improve autistic symptoms, but the underlying mechanisms are not fully understood. In this study, we evaluated the effects of human-derived FMT on behavioral and multi-omics profiles of the BTBR mice, an established model for ASD. FMT effectively alleviated the social deficits in the BTBR mice and normalized their distinct plasma metabolic profile, notably reducing the elevated long-chain acylcarnitines. Integrative analysis linked these phenotypic changes to specific\n              <jats:italic>Bacteroides<\/jats:italic>\n              species and vitamin B\n              <jats:sub>6<\/jats:sub>\n              metabolism. Indeed, vitamin B\n              <jats:sub>6<\/jats:sub>\n              supplementation improved the social behaviors in BTBR mice. Collectively, these findings shed new light on the interplay between FMT and vitamin B\n              <jats:sub>6<\/jats:sub>\n              metabolism and revealed a potential mechanism underlying the therapeutic role of FMT in ASD.\n            <\/jats:p>\n            <jats:sec>\n              <jats:title>IMPORTANCE<\/jats:title>\n              <jats:p>\n                Accumulating evidence supports the beneficial effects of human fecal microbiota transplantation (FMT) on symptoms associated with autism spectrum disorder (ASD). However, the precise mechanism by which FMT induces a shift in the microbiota and leads to symptom improvement remains incompletely understood. This study integrated data from colon-content metagenomics, colon-content metabolomics, and plasma metabolomics to investigate the effects of FMT treatment on the BTBR mouse model for ASD. The analysis linked the amelioration of social deficits following FMT treatment to the restoration of mitochondrial function and the modulation of vitamin B\n                <jats:sub>6<\/jats:sub>\n                metabolism. Bacterial species and compounds with beneficial roles in vitamin B\n                <jats:sub>6<\/jats:sub>\n                metabolism and mitochondrial function may further contribute to improving FMT products and designing novel therapies for ASD treatment.\n              <\/jats:p>\n            <\/jats:sec>\n          <\/jats:sec>","DOI":"10.1128\/msystems.00257-24","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T13:00:34Z","timestamp":1716469234000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Human-derived fecal microbiota transplantation alleviates social deficits of the BTBR mouse model of autism through a potential mechanism involving vitamin B\n            <sub>6<\/sub>\n            metabolism"],"prefix":"10.1128","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1789-0698","authenticated-orcid":false,"given":"Lifeng","family":"Zheng","sequence":"first","affiliation":[{"name":"Brain Research Centre and Department of Neuroscience, Southern University of Science and Technology, Shenzhen, China"},{"name":"Xbiome Co. Ltd., Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0124-8729","authenticated-orcid":false,"given":"Yinming","family":"Jiao","sequence":"additional","affiliation":[{"name":"Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1466-8629","authenticated-orcid":false,"given":"Haolin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Brain Research Centre and Department of Neuroscience, Southern University of Science and Technology, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tan","sequence":"additional","affiliation":[{"name":"Xbiome Co. Ltd., Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Yin","sequence":"additional","affiliation":[{"name":"Xbiome Co. Ltd., Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Xbiome Co. Ltd., Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Liu","sequence":"additional","affiliation":[{"name":"Xbiome Co. Ltd., Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manli","family":"Wu","sequence":"additional","affiliation":[{"name":"Xbiome Co. Ltd., Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqun","family":"Huang","sequence":"additional","affiliation":[{"name":"Xbiome Co. Ltd., Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen Institute for Drug Control, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirong","family":"Qin","sequence":"additional","affiliation":[{"name":"Shenzhen Institute for Drug Control, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5989-5377","authenticated-orcid":false,"given":"Mingbang","family":"Wang","sequence":"additional","affiliation":[{"name":"Microbiome Therapy Center, South China Hospital, Medical School, Shenzhen University, Shenzhen, China"},{"name":"Shanghai Key Laboratory of Birth Defects, Division of Neonatology, Children\u2019s Hospital of Fudan University, National Center for Children\u2019s Health, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-4967","authenticated-orcid":false,"given":"Yang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Hematology, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiying","family":"Lv","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangzi","family":"Luo","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1609-0840","authenticated-orcid":false,"given":"Han","family":"Hu","sequence":"additional","affiliation":[{"name":"Xbiome Co. Ltd., Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9736-342X","authenticated-orcid":false,"given":"Sheng-Tao","family":"Hou","sequence":"additional","affiliation":[{"name":"Brain Research Centre and Department of Neuroscience, Southern University of Science and Technology, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1416-1601","authenticated-orcid":false,"given":"Ling","family":"Kui","sequence":"additional","affiliation":[{"name":"Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_5_2_2","volume-title":"Diagnostic and statistical manual of mental disorders: DSM-5TM","year":"2013","unstructured":"Diagnostic and statistical manual of mental disorders: DSM-5TM. 2013. 5th ed. American Psychiatric Publishing, Inc, Arlington, VA, US.","edition":"5"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss7202a1"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-017-0121-4"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwab065"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3992"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4524"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0288-4"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-020-00408-0"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-22"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","unstructured":"Morton JT Jin D-M Mills RH Shao Y Rahman G McDonald D Berding K Needham BD Zurita MF David M et al.. 2022. Multi-omic analysis along the gut-brain axis points to a functional architecture of autism. bioRxiv. doi:10.1101\/2022.02.25.482050","DOI":"10.1101\/2022.02.25.482050"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.03.022"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-00460-0"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46101-0"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0242-1"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.03146"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00321-18"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-325115"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000505363"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.11.024"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.11.018"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.113471"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-016-0110-z"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.04.037"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000478725"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00247"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-016-0225-7"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42183-0"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.759435"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.928785"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-051613"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2019.1687293"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.004"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118497"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9081723"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14030608"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2007.00330.x"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003067"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep45356"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.09.020"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/aur.163"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.201"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041947"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature23909"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.11.036"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222881"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-6-r60"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2020.06.032"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113481"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104158"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.04.027"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00906"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00248-020-01494-w"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113070"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0306-4"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells7070084"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-020-00884-z"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-022-00710-w"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-013-6934-x"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025340"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2014.02.004"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126515"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031222"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874467213666200319125109"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2007.03.016"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1134\/S1990747812050157"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.03.099"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-017-4278-6"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2017.1411412"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02794-5"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00294"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.734837"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2019.114624"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(97)00482-6"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20011452"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba3760"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1080\/10715760410001725517"},{"key":"e_1_3_5_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101567"},{"key":"e_1_3_5_79_2","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2022.2100252"},{"key":"e_1_3_5_80_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00699"},{"key":"e_1_3_5_81_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo10110443"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1036"},{"key":"e_1_3_5_83_2","first-page":"133","article-title":"Autistic-like findings associated with a urea cycle disorder in a 4-year-old girl","volume":"30","author":"G\u00f6rker I","year":"2005","unstructured":"G\u00f6rker I, T\u00fcz\u00fcn U. 2005. Autistic-like findings associated with a urea cycle disorder in a 4-year-old girl. J Psychiatry Neurosci 30:133\u2013135.","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_3_5_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.143"},{"key":"e_1_3_5_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706069"},{"key":"e_1_3_5_86_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13103420"},{"key":"e_1_3_5_87_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00007"},{"key":"e_1_3_5_88_2","first-page":"923","article-title":"Plasma amino acid profile in autism spectrum disorder (ASD)","volume":"20","author":"Bala KA","year":"2016","unstructured":"Bala KA, Do\u011fan M, Mutluer T, Kaba S, Aslan O, Balahoro\u011flu R, \u00c7okluk E, \u00dcstyol L, Kocaman S. 2016. Plasma amino acid profile in autism spectrum disorder (ASD). Eur Rev Med Pharmacol Sci 20:923\u2013929.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_5_89_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071714-034330"},{"key":"e_1_3_5_90_2","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.10"},{"key":"e_1_3_5_91_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.2.333S"},{"key":"e_1_3_5_92_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14112336"},{"key":"e_1_3_5_93_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.01343-20"},{"key":"e_1_3_5_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2022.06.038"},{"key":"e_1_3_5_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2004.01.011"},{"key":"e_1_3_5_96_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-018-0241-7"},{"key":"e_1_3_5_97_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06614.x"},{"key":"e_1_3_5_98_2","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-6-1"},{"key":"e_1_3_5_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2022.577893"},{"key":"e_1_3_5_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2020.100829"},{"key":"e_1_3_5_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.06.027"},{"key":"e_1_3_5_102_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00636"},{"key":"e_1_3_5_103_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.033714"},{"key":"e_1_3_5_104_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19040993"},{"key":"e_1_3_5_105_2","doi-asserted-by":"publisher","DOI":"10.1177\/1362361320959503"},{"key":"e_1_3_5_106_2","unstructured":"Revelle W. 2024. psych: procedures for psychological psychometric and personality research. R package version 2.4.1. Northwestern University Evanston Illinois. Available from: https:\/\/CRAN.R-project.org\/package=psych"},{"key":"e_1_3_5_107_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-559"}],"container-title":["mSystems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.00257-24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.00257-24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T13:05:53Z","timestamp":1718715953000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msystems.00257-24"}},"subtitle":[],"editor":[{"given":"Joshua E.","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,6,18]]},"references-count":106,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6,18]]}},"alternative-id":["10.1128\/msystems.00257-24"],"URL":"https:\/\/doi.org\/10.1128\/msystems.00257-24","relation":{},"ISSN":["2379-5077"],"issn-type":[{"value":"2379-5077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,18]]},"assertion":[{"value":"2024-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00257-24"}}