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Throughout their long evolutionary history, individual herpesvirus species have developed remarkable host specificity, while collectively the\n            <jats:italic>Herpesviridae<\/jats:italic>\n            family has evolved to infect a large variety of eukaryotic hosts. The development of approaches to fight herpesvirus infections has been hampered by the complexity of herpesviruses\u2019 genomes, proteomes, and structural features. The data and insights generated by our study add to the understanding of the functional organization of herpesvirus-encoded proteins, specifically of family-wise conserved features defining essential components required for a productive infectious cycle across different hosts, which can contribute toward the conceptualization of antiherpetic infection strategies with an effect on a broader range of target species. All of the generated data have been made freely available through our HVint2.0 database, a dedicated resource of curated herpesvirus interactomics purposely created to promote and assist future studies in the field.\n          <\/jats:p>","DOI":"10.1128\/msystems.00295-19","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T14:29:44Z","timestamp":1569853784000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Conserved Central Intraviral Protein Interactome of the\n            <i>Herpesviridae<\/i>\n            Family"],"prefix":"10.1128","volume":"4","author":[{"given":"Anna","family":"Hern\u00e1ndez Dur\u00e1n","sequence":"first","affiliation":[{"name":"Institute of Structural and Molecular Biology, Birkbeck College, University of London, London, United Kingdom"},{"name":"Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay","family":"Gr\u00fcnewald","sequence":"additional","affiliation":[{"name":"Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom"},{"name":"Department of Structural Cell Biology of Viruses, Centre for Structural Systems Biology, Heinrich Pette Institute, Leibnitz Institute of Experimental Virology, University of Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Topf","sequence":"additional","affiliation":[{"name":"Institute of Structural and Molecular Biology, Birkbeck College, University of London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511545313"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140765"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00062-12"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2014.82"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.2.725-731.2005"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1116804"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702332104"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000570"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.05.023"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M116.058552"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000316"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/database\/bau131"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1099"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-5-44"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511545313"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511545313"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.19.10179-10185.2003"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-10-2693"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aan1457"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.7.2186"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-53168-7_6"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2017.01.019"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao7298"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201592359"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2004.08.013"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01230-08"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00361-10"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02799-14"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03041-14"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-66-7-1581"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.8.4278-4288.2004"},{"key":"e_1_3_2_33_2","first-page":"750","article-title":"The completeness of molecular biology","volume":"20","author":"Morowitz HJ","year":"1984","unstructured":"Morowitz HJ. 1984. 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