{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:32:54Z","timestamp":1787016774696,"version":"build-2736575974"},"reference-count":53,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:00:00Z","timestamp":1565049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"National High Technology Research and Development Program 863","award":["2015AA020702"],"award-info":[{"award-number":["2015AA020702"]}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Program of Guangdong","doi-asserted-by":"crossref","award":["2016A020217010"],"award-info":[{"award-number":["2016A020217010"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Program of Guangdong","doi-asserted-by":"crossref","award":["2018B020205002"],"award-info":[{"award-number":["2018B020205002"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872630"],"award-info":[{"award-number":["31872630"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2019,8,27]]},"abstract":"<jats:p>\n                    <jats:named-content content-type=\"genus-species\">Cronobacter sakazakii<\/jats:named-content>\n                    is an opportunistic pathogenic bacterium that can cause necrotizing enterocolitis (NEC). However, the mechanism of pathogenicity of\n                    <jats:named-content content-type=\"genus-species\">C. sakazakii<\/jats:named-content>\n                    is largely unknown. Here we have now demonstrated that apoptotic and pyroptotic stimuli are effectors of\n                    <jats:named-content content-type=\"genus-species\">C. sakazakii<\/jats:named-content>\n                    -induced NEC. Previously, we isolated a novel probiotic strain candidate from fecal samples from healthy infants and characterized it as\n                    <jats:named-content content-type=\"genus-species\">Bacteroides fragilis<\/jats:named-content>\n                    strain ZY-312. Functional characterization reveals that ZY-312 inhibited\n                    <jats:named-content content-type=\"genus-species\">C. sakazakii<\/jats:named-content>\n                    invasion, restoring epithelial barrier dysfunction, decreasing the expression of inflammatory cytokines, and reducing dual cell death (pyroptosis and apoptosis). Furthermore, the presence of ZY-132 was sufficient to hinder the adverse reaction seen with\n                    <jats:named-content content-type=\"genus-species\">C. sakazakii<\/jats:named-content>\n                    in a\n                    <jats:named-content content-type=\"genus-species\">C. sakazakii<\/jats:named-content>\n                    -induced NEC model. Taking the results together, our study demonstrated the utility of ZY-312 as a promising probiotic agent for the prevention of NEC.\n                  <\/jats:p>","DOI":"10.1128\/msystems.00305-19","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T08:29:30Z","timestamp":1564993770000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":77,"title":["Bacteroides fragilis Strain ZY-312 Defense against Cronobacter sakazakii-Induced Necrotizing Enterocolitis\n                    <i>In Vitro<\/i>\n                    and in a Neonatal Rat Model"],"prefix":"10.1128","volume":"4","author":[{"given":"Hongying","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 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