{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:45:08Z","timestamp":1792176308922,"version":"4.4.0"},"reference-count":69,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000066","name":"HHS | NIH | National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["1R01ES025547"],"award-info":[{"award-number":["1R01ES025547"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2022,8,30]]},"abstract":"<jats:p>\n            This is the first work to show in a rodent model that\n            <jats:italic>in utero<\/jats:italic>\n            exposure to an opioid drug can lead to longstanding effects on the gut microbiota when examined at adulthood. Further, such bacterial changes are associated with metabolic host responses. Given the similarities between rodent and human microbiomes, it raises cause for concern that similar effects may become evident in children born to mothers taking oxycodone and other opioid drugs.\n          <\/jats:p>","DOI":"10.1128\/msystems.00336-22","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T13:00:37Z","timestamp":1657198837000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Long-Term Effects of Developmental Exposure to Oxycodone on Gut Microbiota and Relationship to Adult Behaviors and Metabolism"],"prefix":"10.1128","volume":"7","author":[{"given":"Zhen","family":"Lyu","sequence":"first","affiliation":[{"name":"Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Christopher S Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA"},{"name":"Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Christopher S Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA"},{"name":"Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison T.","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Christopher S Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA"},{"name":"Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Kinkade","sequence":"additional","affiliation":[{"name":"Department of Christopher S Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA"},{"name":"Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiude","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Christopher S Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA"},{"name":"Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan J.","family":"Bivens","sequence":"additional","affiliation":[{"name":"Department of Genomics Technology Core Facility, University of Missouri, Columbia, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trupti","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri, USA"},{"name":"Department of Christopher S Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA"},{"name":"Department of Health Management and Informatics, University of Missouri, Columbia, Missouri, USA"},{"name":"Department of MU Institute of Data Science and Informatics, University of Missouri, Columbia, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl S.","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, USA"},{"name":"Department of Genetics Area Program, University of Missouri, Columbia, Missouri, USA"},{"name":"Department of Thompson Center for Autism and Neurobehavioral Disorders, University of Missouri, Columbia, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40258-018-0402-x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.3951"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2010.08.011"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000463"},{"key":"e_1_3_2_6_2","unstructured":"CDC. 2019. Basics about opioid use during pregnancy. Accessed https:\/\/www.cdc.gov\/pregnancy\/opioids\/basics.html."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1556740"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2018.12.005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/EN.2015-1350"},{"key":"e_1_3_2_10_2","volume-title":"The epigenome and developmental origins of health and disease.","author":"Rosenfeld CS","year":"2015","unstructured":"Rosenfeld CS. 2015. The epigenome and developmental origins of health and disease. Elsevier."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.11.024"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1535370219883601"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.11.007"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/1060028015606732"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23799"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.147"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20675"},{"key":"e_1_3_2_18_2","first-page":"88","article-title":"Effects of prenatal morphine and cocaine on postnatal behaviors and brain neurotransmitters","volume":"158","author":"Vathy I","year":"1995","unstructured":"Vathy I. 1995. Effects of prenatal morphine and cocaine on postnatal behaviors and brain neurotransmitters. NIDA Res Monogr 158:88\u2013114.","journal-title":"NIDA Res Monogr"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-021-10019-2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.108914"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0150-21.2021"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/MRA.00462-19"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.007674-0"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9102118"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01254-5"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00137"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32219-2"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-021-09993-4"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21915-8"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13124"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz626"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31822f42eb"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081836"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13093295"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab346"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76570-9"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194171"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-007-0156-7"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2017.10.015"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67974-8"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23109"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-018-00731-3"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2006.01.009"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1177\/1535370219851109"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.08.006"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24603"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12609"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.134"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2005.00101.x"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000440107"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1919563117"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4889"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8320"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000080107"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr087"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2016.1234657"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2016.11.162"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0209-9"},{"key":"e_1_3_2_59_2","unstructured":"Paulson JN Pop M Bravo HC. 2013. metagenomeSeq: statistical analysis for sparse high-throughput sequencing. Bioconductor package 1:191."},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0548-6"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/sysbio\/syy054"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa070"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1142\/9789814366496_0024"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx701"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000465"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep23027"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02880-0"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005752"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0381-5-19"}],"container-title":["mSystems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.00336-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.00336-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T19:03:42Z","timestamp":1723403022000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msystems.00336-22"}},"subtitle":[],"editor":[{"given":"Gail","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,30]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8,30]]}},"alternative-id":["10.1128\/msystems.00336-22"],"URL":"https:\/\/doi.org\/10.1128\/msystems.00336-22","relation":{},"ISSN":["2379-5077"],"issn-type":[{"value":"2379-5077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,30]]},"assertion":[{"value":"2022-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00336-22"}}