{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T01:15:00Z","timestamp":1781140500093,"version":"3.54.1"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"BASF | BASF Corporation","award":["California Research Alliance (CARA)"],"award-info":[{"award-number":["California Research Alliance (CARA)"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2024,2,20]]},"abstract":"<jats:p>\n            Systems biology research on host-associated microbiota focuses on two fundamental questions: which microbes are present and how do they interact with each other, their host, and the broader host environment? Metagenomics provides us with a direct answer to the first part of the question: it unveils the microbial inhabitants, e.g., on our skin, and can provide insight into their functional potential. Yet, it falls short in revealing their active role. Metabolomics shows us the chemical composition of the environment in which microbes thrive and the transformation products they produce. In particular, untargeted metabolomics has the potential to observe a diverse set of metabolites and is thus an ideal complement to metagenomics. However, this potential often remains underexplored due to the low annotation rates in MS-based metabolomics and the necessity for multiple experimental chromatographic and mass spectrometric conditions. Beyond detection, prospecting metabolites\u2019 functional role in the host\/microbiome metabolome requires identifying the biological processes and entities involved in their production and biotransformations. In the present study of the human scalp, we developed a strategy to achieve comprehensive structural and functional annotation of the metabolites in the human scalp environment, thus diving one step deeper into the interpretation of \u201comics\u201d data. Leveraging a collection of openly accessible software tools and integrating microbiome data as a source of functional metabolite annotations, we finally identified the specific metabolic niche of\n            <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n            , one of the key players of the human skin microbiome.\n          <\/jats:p>","DOI":"10.1128\/msystems.00356-23","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T14:01:23Z","timestamp":1704981683000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Functional metabolomics of the human scalp: a metabolic niche for\n            <i>Staphylococcus epidermidis<\/i>"],"prefix":"10.1128","volume":"9","author":[{"given":"Louis-F\u00e9lix","family":"Nothias","sequence":"first","affiliation":[{"name":"Collaborative Mass Spectrometry Innovation Center, University of California San Diego, La Jolla, 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