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In this study, we have acquired the first RNA sequencing (RNA-seq) transcriptomes of viral satellites outside plants, as well as the transcriptome of the phage ICP1, a predominant predator of pandemic\n                    <jats:named-content content-type=\"genus-species\">Vibrio cholerae<\/jats:named-content>\n                    . Capsid downregulation, previously observed in an unrelated phage satellite, is conserved among\n                    <jats:underline>p<\/jats:underline>\n                    hage inducible chromosomal island-\n                    <jats:underline>l<\/jats:underline>\n                    ike\n                    <jats:underline>e<\/jats:underline>\n                    lements (PLEs), suggesting that viral satellites are under strong selective pressure to reduce the capsid expression of their larger host viruses. Despite conserved manipulation of capsid expression, PLEs exhibit divergent effects on CTX\u03a6 transcription and mobility. Our results demonstrate that PLEs can influence both their hosts\u2019 resistance to phage and the mobility of virulence-encoding elements, suggesting that PLEs can play a substantial role in shaping\n                    <jats:named-content content-type=\"genus-species\">Vibrio cholerae<\/jats:named-content>\n                    evolution.\n                  <\/jats:p>","DOI":"10.1128\/msystems.00358-20","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T09:29:16Z","timestamp":1602667756000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["A Family of Viral Satellites Manipulates Invading Virus Gene Expression and Can Affect Cholera Toxin Mobilization"],"prefix":"10.1128","volume":"5","author":[{"given":"Zachary K.","family":"Barth","sequence":"first","affiliation":[{"name":"Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Netter","sequence":"additional","affiliation":[{"name":"Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angus","family":"Angermeyer","sequence":"additional","affiliation":[{"name":"Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0139-1600","authenticated-orcid":false,"given":"Kimberley D.","family":"Seed","sequence":"additional","affiliation":[{"name":"Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, California, USA"},{"name":"Chan Zuckerberg Biohub, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000871"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-10-106"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04676.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2019.06.034"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/21541264.2019.1684137"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01347-14"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/v8040111"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006134"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2017.63"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/v10060332"},{"key":"e_1_3_3_12_2","doi-asserted-by":"crossref","unstructured":"Blasdel BG Ceyssens P-J Chevallereau A Debarbieux L Lavigne R. 16 January 2018. 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