{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:05:23Z","timestamp":1785423923049,"version":"3.56.0"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2026,6,23]]},"abstract":"ABSTRACT<\/jats:title>\n \n \n \n Certain hydrogenases are capable of converting the trace amounts of molecular hydrogen constantly present in Earth\u2019s atmosphere to supply cells with a little energy during periods of starvation. Recently, Kropp and colleagues investigated the regulation of one of these \u201chigh-affinity\u201d hydrogenases in response to different growth conditions for the ubiquitous soil bacterium\n Mycobacterium smegmatis<\/jats:italic>\n (A. Kropp, J. D. Archer, M. Jespersen, T. D. Watts, et al., mSystems 11:e01678-25, 2026,\n https:\/\/doi.org\/10.1128\/msystems.01678-25<\/jats:ext-link>\n ). A mutation in the\n gylR<\/jats:italic>\n gene, whose product acts as a positive transcriptional regulator of the genes involved in glycerol catabolism, causes the corresponding mutant strain to grow very slowly on glycerol, while the activity of the high-affinity hydrogenase reached levels more than 50 times higher than those of the wild-type strain of\n M. smegmatis<\/jats:italic>\n . The results of this study suggest that the synthesis of the hydrogenase is subject to a regulatory mechanism similar to carbon catabolite repression, which is entirely consistent with the cellular function of this enzyme.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1128\/msystems.00369-26","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T13:00:17Z","timestamp":1779800417000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Regulation of a catabolic enzyme whose substrate is always available"],"prefix":"10.1128","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4550-5128","authenticated-orcid":true,"given":"Oliver","family":"Lenz","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03v4gjf40","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Chemistry, Biophysical Chemistry, Technische Universit\u00e4t Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1932"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.21.12474"},{"key":"e_1_3_1_4_2","first-page":"255","article-title":"The hydrogen-sensing apparatus in Ralstonia eutropha","volume":"4","author":"Lenz O","year":"2002","unstructured":"Lenz O, Bernhard M, Buhrke T, Schwartz E, Friedrich B. 2002. The hydrogen-sensing apparatus in Ralstonia eutropha. J Mol Microbiol Biotechnol 4:255\u2013262.","journal-title":"J Mol Microbiol Biotechnol"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03364-14"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00724-x"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2506353122"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1320586111"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05781-7"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.011076"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.01678-25"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00511-19"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2025.111358"}],"container-title":["mSystems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.00369-26","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.00369-26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:03:41Z","timestamp":1783515821000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msystems.00369-26"}},"subtitle":[],"editor":[{"given":"Pablo Ivan","family":"Nikel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,23]]}},"alternative-id":["10.1128\/msystems.00369-26"],"URL":"https:\/\/doi.org\/10.1128\/msystems.00369-26","relation":{},"ISSN":["2379-5077"],"issn-type":[{"value":"2379-5077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]},"assertion":[{"value":"2026-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00369-26"}}