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We identified important sclerotium and compound appressorium formation determinants, SsNsd1 and SsFdh1, and investigated their regulatory mechanism at the molecular level. SsNsd1 and SsFdh1 are zinc finger motif-containing proteins and associate with each other in the nucleus. On other hand, SsNsd1, as a GATA transcription factor, directly binds to GATA-box DNA in the promoter region of\n            <jats:italic>Ssfdh1<\/jats:italic>\n            . The SsNsd1-SsFdh1 interaction and nuclear translocation were found to prevent efficient binding of SsNsd1 to GATA-box DNA. Our results provide insights into the role of the GATA transcription factor and its regulation of formaldehyde dehydrogenase in stress resistance, fungal sclerotium and compound appressorium development, and pathogenicity.\n          <\/jats:p>","DOI":"10.1128\/msystems.00397-19","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T12:35:46Z","timestamp":1568032546000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["The Formaldehyde Dehydrogenase SsFdh1 Is Regulated by and Functionally Cooperates with the GATA Transcription Factor SsNsd1 in Sclerotinia sclerotiorum"],"prefix":"10.1128","volume":"4","author":[{"given":"Genglin","family":"Zhu","sequence":"first","affiliation":[{"name":"College of Plant Sciences, Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Plant Sciences, Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Plant Sciences, Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinliang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Plant Sciences, Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Plant Sciences, Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9897-6292","authenticated-orcid":false,"given":"Jeffrey A.","family":"Rollins","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology, University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtao","family":"Li","sequence":"additional","affiliation":[{"name":"College of Plant Sciences, Jilin University, Changchun, China"},{"name":"Key Lab of Integrated Crop Pest Management of Shandong Province, College of Plant Health and Medicine, Qingdao Agricultural University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Plant Sciences, Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/07060669409500766"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evx030"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1094\/Phyto-69-896"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2007.00417.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/mpp.12239"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/mpp.12651"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00307-06"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.13.7.4011"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2008.03.007"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2010.07.011"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(00)00063-1"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19102946"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.6.2491"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120627"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(02)02414-6"},{"key":"e_1_3_2_17_2","first-page":"843","article-title":"Maize glutathione-dependent formaldehyde dehydrogenase cDNA: a novel plant gene of detoxification","volume":"34","author":"Fliegmann J","year":"1997","unstructured":"Fliegmann J, Sandermann J, Jr. 1997. 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