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This study aims at identifying the potential interactions between these two fundamental systems\u2014which form the gut microbiota-endocannabinoidome axis\u2014and their involvement in the establishment of diet-induced obesity and related metabolic complications. We report here time- and segment-specific microbiome disturbances as well as modifications of intestinal and circulating endocannabinoidome mediators during high-fat, high-sucrose diet-induced glucose intolerance and subsequent obesity and hyperinsulinemia. This highlights the involvement of, and the interaction between, the gut microbiota and the endocannabinoidome during metabolic adaptation to high-fat and high-sucrose feeding. These results will help identifying actionable gut microbiome members and\/or endocannabinoidome mediators to improve metabolic health.<\/jats:p>","DOI":"10.1128\/msystems.00407-19","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T07:55:19Z","timestamp":1576482919000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":75,"title":["Rapid and Concomitant Gut Microbiota and Endocannabinoidome Response to Diet-Induced Obesity in Mice"],"prefix":"10.1128","volume":"4","author":[{"given":"S\u00e9bastien","family":"Lacroix","sequence":"first","affiliation":[{"name":"Institut sur la nutrition et les aliments fonctionnels (INAF), Qu\u00e9bec, Qu\u00e9bec, Canada"},{"name":"Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, 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