{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:59:30Z","timestamp":1790171970172,"version":"4.1.0"},"reference-count":36,"publisher":"American Society for Microbiology","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82020108022"],"award-info":[{"award-number":["82020108022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"publisher","award":["2024A 1515030191"],"award-info":[{"award-number":["2024A 1515030191"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Colorectal cancer is among the deadliest malignancies globally. The modern therapies do not lead to ideal outcomes due mostly to drug resistance and recurrence. Previously, we treated cancer patients by ameliorating the gut microbiome and achieved curative effects. We hypothesize that anticancer bacteria might be ubiquitous in the gut but suppressed under certain conditions, pointing to a possibility that an ameliorated gut ecology may help regain the abundance or functions of the hypothetical anticancer bacteria. Here, we show our successful isolation and polyphasic characterization of a gut bacterial strain, CGMCC 17111, which exhibited potent suppressive effects on colorectal cancer. CGMCC 17111 belongs to\n                      <jats:italic toggle=\"yes\">Streptomyces<\/jats:italic>\n                      and is most closely related to the type strain of\n                      <jats:italic toggle=\"yes\">Streptomyces albidoflavus<\/jats:italic>\n                      , DSM 40455\n                      <jats:sup>T<\/jats:sup>\n                      . However, DSM 40455\n                      <jats:sup>T<\/jats:sup>\n                      does not show any appreciable anticancer effects. Genetic, phenotypic, and functional analyses established CGMCC 17111 as representing a novel gut bacterial species with peculiar activities to redress malignancy without eliciting violent inflammatory reactions in the host.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>IMPORTANCE<\/jats:title>\n                    <jats:p>\n                      The human gut bacterial strain\n                      <jats:italic toggle=\"yes\">Streptomyces<\/jats:italic>\n                      sp. CGMCC 17111 represents a genetically distinct gut-derived\n                      <jats:italic toggle=\"yes\">Streptomyces<\/jats:italic>\n                      lineage that exhibited antitumor activity in both\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      experimental models. As a resident member of the human gut microbiota, CGMCC 17111 may contribute to host\u2013microbiota interactions that influence tumor-associated biological processes. The findings of this study provide a foundation for future research into gut-derived microbial products and their potential applications in cancer therapy while preserving host physiological homeostasis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/msystems.00528-26","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:01:26Z","timestamp":1790168486000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["A novel human\n                    <i>Streptomyces<\/i>\n                    strain redresses malignancy by inducing apoptosis and regaining gut homeostasis"],"prefix":"10.1128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8780-7725","authenticated-orcid":false,"given":"Yu-Hui","family":"Wang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05jscf583","id-type":"ROR","asserted-by":"publisher"}],"name":"Genomics 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Juan","family":"Yuan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05jscf583","id-type":"ROR","asserted-by":"publisher"}],"name":"Genomics Research Center (Key Laboratory of Gut Microbiota and Pharmacogenomics of Heilongjiang Province, State-Province Key Laboratory of Biomedicine-Pharmaceutics of China), College of Pharmacy, Harbin Medical University","place":["Harbin, China"]},{"id":[{"id":"https:\/\/ror.org\/05jscf583","id-type":"ROR","asserted-by":"publisher"}],"name":"Harbin Medical University-University of Calgary Cumming School of Medicine Centre for Infection and Genomics, Harbin Medical University","place":["Harbin, China"]},{"id":[{"id":"https:\/\/ror.org\/05jscf583","id-type":"ROR","asserted-by":"publisher"}],"name":"State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University","place":["Harbin, 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Pursuing the origin of pathogenic bacterial species. 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