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In an effort to identify new drug candidates for lymphatic filariasis, we conducted a three-way transcriptomics\/systems biology study of one of the causative agents of lymphatic filariasis,\n            <jats:named-content content-type=\"genus-species\">Brugia malayi<\/jats:named-content>\n            , its\n            <jats:italic>Wolbachia<\/jats:italic>\n            endosymbiont\n            <jats:italic>w<\/jats:italic>\n            Bm, and its vector host\n            <jats:named-content content-type=\"genus-species\">Aedes aegypti<\/jats:named-content>\n            at 16 distinct\n            <jats:named-content content-type=\"genus-species\">B. malayi<\/jats:named-content>\n            life stages.\n            <jats:named-content content-type=\"genus-species\">B. malayi<\/jats:named-content>\n            upregulates the expression of bromodomain-containing proteins in the adult female, embryo, and microfilaria stages.\n            <jats:italic>In vitro<\/jats:italic>\n            , we find that the existing cancer therapeutic JQ1(+), which is a bromodomain and extraterminal protein inhibitor, has adulticidal activity in\n            <jats:named-content content-type=\"genus-species\">B. malayi<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/msystems.00596-19","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T11:46:57Z","timestamp":1575287217000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Drug Repurposing of Bromodomain Inhibitors as Potential Novel Therapeutic Leads for Lymphatic Filariasis Guided by Multispecies Transcriptomics"],"prefix":"10.1128","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9545-523X","authenticated-orcid":false,"given":"Matthew","family":"Chung","sequence":"first","affiliation":[{"name":"Institute for Genome Sciences, University of Maryland School of Medicine, 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