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Given the limited therapeutic possibilities, effective prevention strategies, e.g., a vaccine, or the early identification of high-risk patients would be important but are not available. Our study showed an acute-phase response in patients with\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            bloodstream infection and evidence that lipoproteins are downregulated in plasma. Using immunoproteomics, stratification of patients appears to be achievable, since at the early stages of systemic\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            infection patients had low preexisting anti-\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            antibody levels. This strengthens the notion that a robust immune memory for\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            protects against infections with the pathogen.\n          <\/jats:p>","DOI":"10.1128\/msystems.00632-19","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T09:38:23Z","timestamp":1579513103000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Early-Stage\n            <i>Staphylococcus aureus<\/i>\n            Bloodstream Infection Causes Changes in the Concentrations of Lipoproteins and Acute-Phase Proteins and Is Associated with Low Antibody Titers against Bacterial Virulence Factors"],"prefix":"10.1128","volume":"5","author":[{"given":"Stephan","family":"Michalik","sequence":"first","affiliation":[{"name":"Department Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, 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