{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:03:21Z","timestamp":1790895801296,"version":"4.1.0"},"reference-count":58,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2020,10,27]]},"abstract":"<jats:p>\n            Alternative antimicrobials, such as metals, are one of the methods currently used to help mitigate antibiotic resistance. Metal-based antimicrobials such as copper and silver are used currently both to prevent and to treat infections. Although the efficacy of these antimicrobials has been determined in single-species culture, bacteria rarely exist in a single-species group in the environment. Both\n            <jats:named-content content-type=\"genus-species\">Pseudomonas aeruginosa<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            are often found associated with each other in severe chronic infections displaying increased virulence and antibiotic tolerance. In this study, we determined that multiple compounds secreted by\n            <jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>\n            are able to increase the tolerance of\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            to both copper and silver. This work demonstrates the expansive chemical communication occurring in polymicrobial infections between bacteria.\n          <\/jats:p>","DOI":"10.1128\/msystems.00746-20","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T13:23:30Z","timestamp":1599485010000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Multiple Compounds Secreted by\n            <i>Pseudomonas aeruginosa<\/i>\n            Increase the Tolerance of\n            <i>Staphylococcus aureus<\/i>\n            to the Antimicrobial Metals Copper and Silver"],"prefix":"10.1128","volume":"5","author":[{"given":"Nadia K.","family":"Monych","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-0776","authenticated-orcid":false,"given":"Raymond J.","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199855030-00001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e3282f37a11"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6963910"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00181-19"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2016.05.046"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics8010008"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.12.002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/nano10020292"},{"key":"e_1_3_2_10_2","first-page":"80","article-title":"Historic uses of copper compounds in medicine","volume":"2","author":"Dollwet H","year":"1985","unstructured":"Dollwet H, Sorenson J. 1985. 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