{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:47:56Z","timestamp":1788821276666,"version":"build-2803163510"},"reference-count":70,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["21K17196, 23K16222"],"award-info":[{"award-number":["21K17196, 23K16222"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["22H03300, 22K19622"],"award-info":[{"award-number":["22H03300, 22K19622"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["22K10311"],"award-info":[{"award-number":["22K10311"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["22H00487, 21K18281"],"award-info":[{"award-number":["22H00487, 21K18281"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2024,2,20]]},"abstract":"<jats:p>\n            Halitosis can have a significant impact on the social life of affected individuals. Among oral odor compounds, CH\n            <jats:sub>3<\/jats:sub>\n            SH has a low olfactory threshold and halitosis is a result of its production. Recently, there has been a growing interest in the collective properties of oral polymicrobial communities, regarded as important for the development of oral diseases, which are shaped by physical and metabolic interactions among community participants. However, it has yet to be investigated whether interspecies interactions have an impact on the production of volatile compounds, leading to the development of halitosis. The present findings provide mechanistic insights indicating that ornithine, a metabolite excreted by\n            <jats:italic>Streptococcus gordonii<\/jats:italic>\n            , promotes polyamine synthesis by\n            <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n            , resulting in a compensatory increase in demand for methionine, which results in elevated methionine pathway activity and CH\n            <jats:sub>3<\/jats:sub>\n            SH production. Elucidation of the mechanisms related to CH\n            <jats:sub>3<\/jats:sub>\n            SH production is expected to lead to the development of new strategies for managing halitosis.\n          <\/jats:p>","DOI":"10.1128\/msystems.00764-23","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T14:01:03Z","timestamp":1706623263000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Interspecies metabolite transfer fuels the methionine metabolism of\n            <i>Fusobacterium nucleatum<\/i>\n            to stimulate volatile methyl mercaptan production"],"prefix":"10.1128","volume":"9","author":[{"given":"Takeshi","family":"Hara","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan"},{"name":"Advanced Technology Institute, Mandom Corporation, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akito","family":"Sakanaka","sequence":"additional","affiliation":[{"name":"Department of Preventive Density, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3147-5039","authenticated-orcid":true,"given":"Richard J.","family":"Lamont","sequence":"additional","affiliation":[{"name":"Department of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Preventive Density, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3332-2431","authenticated-orcid":false,"given":"Masae","family":"Kuboniwa","sequence":"additional","affiliation":[{"name":"Department of Preventive Density, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.09.036"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(08)70002-5"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01890.x"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.5.485"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028009813.x"},{"key":"e_1_3_4_7_2","first-page":"118","volume-title":"Odor measurement review","author":"Nagata Y","year":"2003","unstructured":"Nagata Y. 2003. Measurement of odor threshold by triangle odor bag method, p 118\u2013127. In Odor measurement review. Japan Ministry of the environment, Japan."},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280111.x"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/7\/1\/017114"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-595x.2002.tb00933.x"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1992.tb01736.x"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1996.tb00499.x"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1992.tb01820.x"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-595x.2002.tb00928.x"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1286-4579(02)01586-1"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.12.6912-6916.2000"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(02)02958-7"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302x.1990.tb00411.x"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302x.1990.tb00645.x"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00886-21"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38346-3"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.02.010"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2023.02.009"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-020-00865-y"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1919099117"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800261-2.00002-5"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07707.x"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05099.x"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00439-09"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2017.1326438"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.7.3983-3989.2005"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.057182-0"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.1.274-284.2003"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00546-09"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00554-07"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407457101"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-017-0021-6"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.644401"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.5.1374-1382.2000"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412660200"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2000069"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017510"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.10.004"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00107"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.11.5549-5553.2002"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121744"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2790675"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0141-0229(85)90094-8"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2016.05.010"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-12-189"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(91)90091-8"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-29134-6"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0089-x"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.00170-22"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.4.8647346"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.077826-0"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07455.x"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/iub.278"},{"key":"e_1_3_4_59_2","first-page":"145","article-title":"Sulfur metabolism in Escherichia coli and related bacteria: facts and fiction","volume":"2","author":"Sekowska A","year":"2000","unstructured":"Sekowska A, Kung HF, Danchin A. 2000. Sulfur metabolism in Escherichia coli and related bacteria: facts and fiction. J Mol Microbiol Biotechnol 2:145\u2013177.","journal-title":"J Mol Microbiol Biotechnol"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1146"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1916"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.04.016"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.49.1.81-99.1985"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3440633"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06126.x"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302x.1990.tb00418.x"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.12.6558-6564.1999"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1711625114"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00855-16"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1087"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(67)90158-1"}],"container-title":["mSystems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.00764-23","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.00764-23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T14:02:09Z","timestamp":1708437729000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msystems.00764-23"}},"subtitle":[],"editor":[{"given":"Promi","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,2,20]]},"references-count":70,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2,20]]}},"alternative-id":["10.1128\/msystems.00764-23"],"URL":"https:\/\/doi.org\/10.1128\/msystems.00764-23","relation":{},"ISSN":["2379-5077"],"issn-type":[{"value":"2379-5077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,20]]},"assertion":[{"value":"2023-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00764-23"}}