{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:04:11Z","timestamp":1773075851266,"version":"3.50.1"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81870457"],"award-info":[{"award-number":["81870457"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82172944"],"award-info":[{"award-number":["82172944"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81900558"],"award-info":[{"award-number":["81900558"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key science and technology project s of Henan Province","award":["232102311048"],"award-info":[{"award-number":["232102311048"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2024,9,17]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              Budd-Chiari syndrome (B-CS) is a rare and lethal condition characterized by hepatic venous outflow tract blockage. Gut microbiota has been linked to numerous hepatic disorders, but its significance in B-CS pathogenesis is uncertain. First, we performed a case-control study (\n              <jats:italic>N<\/jats:italic>\n              <jats:sub>case<\/jats:sub>\n              = 140,\n              <jats:italic>N<\/jats:italic>\n              <jats:sub>control<\/jats:sub>\n              = 63) to compare the fecal microbiota of B-CS and healthy individuals by metagenomics sequencing. B-CS patients\u2019 gut microbial composition and activity changed significantly, with a different metagenomic makeup, increased potentially pathogenic bacteria, including\n              <jats:italic>Prevotella<\/jats:italic>\n              , and disease-linked microbial function. Imbalanced cytokines in patients were demonstrated to be associated with gut dysbiosis, which led us to suspect that B-CS is associated with gut microbiota and immune dysregulation. Next, 16S ribosomal DNA sequencing on fecal microbiota transplantation (FMT) mice models examined the link between gut dysbiosis and B-CS. FMT models showed damaged liver tissues, posterior inferior vena cava, and increased\n              <jats:italic>Prevotella<\/jats:italic>\n              in the disturbed gut microbiota of FMT mice. Notably, B-CS-FMT impaired the morphological structure of colonic tissues and increased intestinal permeability. Furthermore, a significant increase of the same cytokines (IL-5, IL-6, IL-9, IL-10, IL-17A, IL-17F, and IL-13) and endotoxin levels in B-CS-FMT mice were observed. Our study suggested that gut microbial dysbiosis may cause B-CS through immunological dysregulation.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>IMPORTANCE<\/jats:title>\n            <jats:p>\n              This study revealed that gut microbial dysbiosis may cause Budd-Chiari syndrome (B-CS). Gut dysbiosis enhanced intestinal permeability, and toxic metabolites and imbalanced cytokines activated the immune system. Consequently, the escalation of causative factors led to their concentration in the portal vein, thereby compromising both the liver parenchyma and outflow tract. Therefore, we proposed that gut microbial dysbiosis induced immune imbalance by chronic systemic inflammation, which contributed to the B-CS development. Furthermore,\n              <jats:italic>Prevotella<\/jats:italic>\n              may mediate inflammation development and immune imbalance, showing potential in B-CS pathogenesis.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/msystems.00794-24","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T01:02:24Z","timestamp":1724288544000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Gut dysbiosis contributes to the development of Budd-Chiari syndrome through immune imbalance"],"prefix":"10.1128","volume":"9","author":[{"given":"Qinwei","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Institute of Hepatobiliary and Pancreatic Diseases, Zhengzhou University, Zhengzhou, China"},{"name":"Key Lab of Hepatobiliary and Pancreatic Diseases, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongtao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Institute of Hepatobiliary and Pancreatic Diseases, Zhengzhou University, Zhengzhou, China"},{"name":"Key Lab of Hepatobiliary and Pancreatic Diseases, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Hepatobiliary and Pancreatic Diseases, Zhengzhou University, Zhengzhou, China"},{"name":"Key Lab of Hepatobiliary and Pancreatic Diseases, Zhengzhou, China"},{"name":"Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruifang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Diagnosis, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endovascular Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhuang","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dechao","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 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