{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:03:26Z","timestamp":1785420206388,"version":"3.56.0"},"reference-count":87,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671479"],"award-info":[{"award-number":["81671479"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"74th bath of General Funding from the China Postdoctoral Science Foundation","award":["2023M740774"],"award-info":[{"award-number":["2023M740774"]}]},{"name":"Guangdong Provincial People's Hospital, Postdoctoral research Launch Fund","award":["BY012022017"],"award-info":[{"award-number":["BY012022017"]}]},{"name":"Guangdong Province Basic and Applied Basic Research Fund Project","award":["2022A1515110447"],"award-info":[{"award-number":["2022A1515110447"]}]},{"name":"Open fund Project of the State Key Laboratory of Applied Microbiology in South China","award":["SKLAM006-2022"],"award-info":[{"award-number":["SKLAM006-2022"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2025,9,23]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Advanced maternal age is associated with adverse pregnancy outcomes. However, the impact of changes in maternal physiology, biochemistry, vaginal microbiome, and its metabolites related to reproductive age on pregnancy outcomes is uncertain. Multi-omics were used to analyze vaginal samples collected from 195 pregnant women of different age groups to characterize the factors affecting the occurrence of adverse pregnancy outcomes in older mothers. Results showed that advanced maternal age is associated with a higher risk of premature birth. Furthermore, columnar ectopy may also contribute to premature birth. Moreover, older mothers with columnar ectopy exhibited vaginal microbiome dysbiosis, characterized by an increase in\n                      <jats:italic toggle=\"yes\">Gardnerella vaginalis<\/jats:italic>\n                      and a reduction in\n                      <jats:italic toggle=\"yes\">Lactobacillus crispatus<\/jats:italic>\n                      . Functional analysis of the microbiome revealed that disruptions in the vaginal microbiome might contribute to columnar ectopy by influencing carbohydrate metabolism in the host, such as galactose metabolism. Finally, galactose-degrading enzymes of\n                      <jats:italic toggle=\"yes\">L. crispatus<\/jats:italic>\n                      were enriched in older mothers with non-columnar ectopies. In addition,\n                      <jats:italic toggle=\"yes\">G. vaginalis<\/jats:italic>\n                      promoted the occurrence of columnar ectopy, whereas the dominance of galactosidase in\n                      <jats:italic toggle=\"yes\">L. crispatus<\/jats:italic>\n                      was protective against columnar ectopy. Our findings demonstrate that\n                      <jats:italic toggle=\"yes\">L. crispatus<\/jats:italic>\n                      is a target to prevent columnar ectopy or age-associated premature birth.\n                      <jats:italic toggle=\"yes\">G. vaginalis<\/jats:italic>\n                      and galactose can be diagnostic markers for the occurrence of adverse pregnancy outcomes in older mothers.\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        Advanced maternal age poses a growing challenge to maternal health globally, yet the mechanisms linking age-related physiological changes to adverse pregnancy outcomes remain unclear. This study identifies vaginal microbiome dysbiosis, characterized by increased\n                        <jats:italic toggle=\"yes\">Gardnerella vaginalis<\/jats:italic>\n                        and reduced\n                        <jats:italic toggle=\"yes\">Lactobacillus crispatus<\/jats:italic>\n                        , as a critical mediator of age-associated preterm birth in mothers with columnar ectopy. By integrating multi-omics analyses, we reveal that disruptions in galactose metabolism driven by microbial shifts may contribute to columnar ectopy development. Notably,\n                        <jats:italic toggle=\"yes\">L. crispatus<\/jats:italic>\n                        galactosidase activity emerges as a protective factor, while\n                        <jats:italic toggle=\"yes\">G. vaginalis<\/jats:italic>\n                        and galactose accumulation serve as potential diagnostic markers. These findings provide actionable targets for microbiome-based interventions to mitigate age-related pregnancy complications, advancing personalized strategies for maternal care.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/msystems.00825-25","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T15:09:26Z","timestamp":1755270566000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Increased vaginal\n                    <i>Gardnerella vaginalis<\/i>\n                    abundance and reduced D-galactose metabolism are associated with preterm birth in older mothers with columnar ectopy in South China"],"prefix":"10.1128","volume":"10","author":[{"given":"Xiaohong","family":"Wang","sequence":"first","affiliation":[{"name":"Obstetrical Department, The Sixth Affiliated Hospital of Sun Yat-sen University","place":["Guangzhou, China"]},{"id":[{"id":"https:\/\/ror.org\/00b3tsf98","id-type":"ROR","asserted-by":"publisher"}],"name":"Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Ministry of Education","place":["Guangzhou, China"]},{"name":"Biomedical Innovation Center, The Sixth Afiliated Hospital, Sun Yat-sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6110-9305","authenticated-orcid":true,"given":"Tingting","family":"Liang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01g9hkj35","id-type":"ROR","asserted-by":"publisher"}],"name":"Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Institute of Microbiology, Guangdong Academy of Sciences","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Liang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/017zhmm22","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Rehabilitation Hospital Pain Ward, Honghui Hospital, Xi'an Jiaotong University","place":["Xi'an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Jiang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01g9hkj35","id-type":"ROR","asserted-by":"publisher"}],"name":"Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Institute of Microbiology, Guangdong Academy of Sciences","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Chen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01g9hkj35","id-type":"ROR","asserted-by":"publisher"}],"name":"Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Institute of Microbiology, Guangdong Academy of Sciences","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Chen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01g9hkj35","id-type":"ROR","asserted-by":"publisher"}],"name":"Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Institute of Microbiology, Guangdong Academy of Sciences","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-0973","authenticated-orcid":false,"given":"Bo","family":"Dong","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/017zhmm22","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Rehabilitation Hospital Pain Ward, Honghui Hospital, Xi'an Jiaotong University","place":["Xi'an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6503-359X","authenticated-orcid":false,"given":"Qingping","family":"Wu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01g9hkj35","id-type":"ROR","asserted-by":"publisher"}],"name":"Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Institute of Microbiology, Guangdong Academy of Sciences","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4897-5993","authenticated-orcid":false,"given":"Yu","family":"Gao","sequence":"additional","affiliation":[{"name":"Obstetrical Department, The Sixth Affiliated Hospital of Sun Yat-sen University","place":["Guangzhou, China"]},{"id":[{"id":"https:\/\/ror.org\/00b3tsf98","id-type":"ROR","asserted-by":"publisher"}],"name":"Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Ministry of Education","place":["Guangzhou, China"]},{"name":"Biomedical Innovation Center, The Sixth Afiliated Hospital, Sun Yat-sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01076-22"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/13625187.2018.1455085"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.07.1338"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.08.034"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/women1040022"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1540-0"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-018-1984-x"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000018"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056583"},{"key":"e_1_3_4_11_2","volume-title":"Exploring the human intestinal microbiome in health and disease","author":"Dicksved J","year":"2008","unstructured":"Dicksved J. 2008. Exploring the human intestinal microbiome in health and disease. Swedish University of Agricultural Sciences Uppsala."},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.03.002"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0450-2"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002611107"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/2049-2618-1-29"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705899114"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(01)00495-7"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-016-0223-9"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02039-21"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-020-00162-8"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.00017-22"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-021-00261-0"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb11010.x"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00001"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01293-8"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.149257"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40719-7"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-019-0667-9"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00449-014-1228-z"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13195"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-019-2400-x"},{"key":"e_1_3_4_32_2","first-page":"159","article-title":"The effect of maternal age on pregnancy outcome","volume":"2","author":"Rajaee M","year":"2010","unstructured":"Rajaee M, Amirzadeh S, Mirblook F, Soltani MA. 2010. The effect of maternal age on pregnancy outcome. Asian J Med Sci 2:159\u2013162.","journal-title":"Asian J Med Sci"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191002"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00476"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09285-9"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2022.103648"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2013.08.019"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1446"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.01.167"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13797"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf176"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14368"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.4696"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016340802005126"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2004.10.010"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14102108"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01089-8"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa011"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-018-0653-x"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez065"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31930-5"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.2605"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.01.029"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12961"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1728-4457.2016.00105.x"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-016-1028-3"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-03030-2"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.08.028"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39849-9"},{"key":"e_1_3_4_61_2","volume-title":"Prenatal tests: The facts","author":"Crespigny L","year":"2006","unstructured":"CrespignyL, Chervenak FA. 2006. Prenatal tests: The facts. Oxford University Press."},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000992"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2011.02.002"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-020-00817-w"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgwh.2021.777643"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1781810"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1159\/000089457"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-022-01317-9"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.453654"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.034280-0"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.3390\/md16060181"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.15.4895-4904.1993"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-116"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01070-7"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.07.007"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2010.00943.x"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01799450"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0494-4"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49619-w"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.665243"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0209-9"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty560"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp324"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv033"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3176"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.135412"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.3168\/jdsc.2021-0145"}],"container-title":["mSystems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.00825-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.00825-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:01:12Z","timestamp":1758632472000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msystems.00825-25"}},"subtitle":[],"editor":[{"given":"Nicole J.","family":"De Nisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,9,23]]},"references-count":87,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,23]]}},"alternative-id":["10.1128\/msystems.00825-25"],"URL":"https:\/\/doi.org\/10.1128\/msystems.00825-25","relation":{},"ISSN":["2379-5077"],"issn-type":[{"value":"2379-5077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,23]]},"assertion":[{"value":"2025-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00825-25"}}