{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:34:37Z","timestamp":1788381277329,"version":"build-2803163510"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2026,3,24]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Listeria monocytogenes<\/jats:italic>\n                      , as a significant foodborne pathogen, is not frequently encountered; however, when infections do occur, they can prove highly lethal to specific populations. Antibiotics are still regarded as the primary treatment option for\n                      <jats:italic toggle=\"yes\">Listeria<\/jats:italic>\n                      infections. Nevertheless, under the global antibiotic crisis, there is an urgent demand for innovative and alternative strategies. In our study, we identified taurine, a sulfur-containing free amino acid that can be extracted from a wide variety of foods, as an effective inhibitor of\n                      <jats:italic toggle=\"yes\">Listeria<\/jats:italic>\n                      growth. Furthermore, our findings revealed that taurine administration significantly reduced bacterial burden and concurrently mitigated host-derived inflammation in the mouse model. It was observed that taurine stimulated T-cell proliferation and inhibited pyroptosis via mitogen-activated protein kinase and NLRP3\/caspase-1\/GSDMD pathways. Our research outcomes position taurine as a promising therapeutic candidate for combating\n                      <jats:italic toggle=\"yes\">Listeria<\/jats:italic>\n                      infections, with an inherent advantage of reduced likelihood for inducing antibiotic resistance compared to conventional antibiotic treatments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>IMPORTANCE<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Listeria monocytogenes<\/jats:italic>\n                      infections are lethal to specific groups. With the antibiotic crisis, new treatments are needed. Taurine, a safe dietary compound, was found to inhibit\n                      <jats:italic toggle=\"yes\">Listeria<\/jats:italic>\n                      growth. It targets both\n                      <jats:italic toggle=\"yes\">L. monocytogenes<\/jats:italic>\n                      virulence and host immunopathology, stimulated T-cell proliferation, and inhibited pyroptosis. We establish taurine as the non-antibiotic agent that decouples bacterial cytotoxicity from inflammation-driven tissue damage, offering an immediately translatable strategy for high-risk infections amid the antibiotic resistance crisis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/msystems.01043-25","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:00:16Z","timestamp":1770040816000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Taurine attenuates\n                    <i>Listeria monocytogenes<\/i>\n                    -induced inflammation and pyroptosis in mouse model by regulating MAPK and NLRP3\/caspase-1\/GSDMD 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