{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:44:47Z","timestamp":1789749887478,"version":"4.0.1"},"reference-count":61,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970555"],"award-info":[{"award-number":["81970555"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC2020CR2014A"],"award-info":[{"award-number":["SHDC2020CR2014A"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2022,6,28]]},"abstract":"<jats:p>\n            We demonstrate that AP patients and experimental AP mice exhibited a dysfunction of Paneth cells. Our\n            <jats:italic>in vivo<\/jats:italic>\n            research showed that the severity of AP was exacerbated by the long-term dysfunction of Paneth cells, which was associated with gut microbiota disorder.\n          <\/jats:p>","DOI":"10.1128\/msystems.01507-21","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T08:30:15Z","timestamp":1651480215000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Paneth Cells Protect against Acute Pancreatitis via Modulating Gut Microbiota Dysbiosis"],"prefix":"10.1128","volume":"7","author":[{"given":"Yang","family":"Fu","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixiang","family":"Mei","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuoming","family":"Yin","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehua","family":"Huang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiwen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengzheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binqiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlan","family":"Huang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zeng","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.08.063"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31310-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2009.08.019"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2003.00410.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000355"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-010-9249-5"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-002-8412-z"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1825"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2546"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09637"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07416"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.51.7.512"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.190728"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8474523"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.08.044"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2018.1474321"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12609"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2015.06.011"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170418"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12744"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1875796"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/145749690909800405"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.03.037"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2316"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.003"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307226"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2013.09.006"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30945"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-401166"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176583"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1080\/1040841X.2019.1621795"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2013.00414.x"},{"key":"e_1_3_2_34_2","first-page":"349","article-title":"The role of intestinal mucosa oxidative stress in gut barrier dysfunction of severe acute pancreatitis","volume":"17","author":"Tian R","year":"2013","unstructured":"Tian R, Tan J-T, Wang R-L, Xie H, Qian Y-B, Yu K-L. 2013. The role of intestinal mucosa oxidative stress in gut barrier dysfunction of severe acute pancreatitis. Eur Rev Med Pharmacol Sci 17:349\u2013355.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1782156"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.11.015"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00059-19"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01065-2"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1770042"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-320135"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.01.003"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.48.3.720-728.1985"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115407"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006512"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.07.010"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00202"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aax6085"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.616218"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.036"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317842"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100232"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.12.010"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3233"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601583"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf803133b"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108633"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1734423"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.124230"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-020-00581-5"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200008000-00005"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1970.01340280030009"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10274"}],"container-title":["mSystems"],"original-title":[],"contributor":[{"given":"Kazuyuki","family":"Kasahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]},{"given":"Pradeep","family":"Bist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]}],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.01507-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.01507-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T13:12:08Z","timestamp":1656421928000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msystems.01507-21"}},"subtitle":[],"editor":[{"given":"Janet K.","family":"Jansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,6,28]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6,28]]}},"alternative-id":["10.1128\/msystems.01507-21"],"URL":"https:\/\/doi.org\/10.1128\/msystems.01507-21","relation":{},"ISSN":["2379-5077"],"issn-type":[{"value":"2379-5077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,28]]},"assertion":[{"value":"2021-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01507-21"}}