{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:24Z","timestamp":1792787244087,"version":"4.5.0"},"reference-count":64,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305241"],"award-info":[{"award-number":["82305241"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ZHEJIANG PROVINCIAL TRADITIONAL CHINESE SCIENCE AND TEHNOLOGY PLAN","award":["2024ZL005"],"award-info":[{"award-number":["2024ZL005"]}]},{"name":"A PROJECT FUNDED BY THE PRIORITY ACADEMIC PROGRAM DEVELOPMENT OF JIANGSU HIGHER EDUCATION INSTITUTIONS","award":["PAPD"],"award-info":[{"award-number":["PAPD"]}]},{"name":"JIANGSU PROVINCIAL MEDICAL KEY LABORATORY","award":["ZDXYS202208"],"award-info":[{"award-number":["ZDXYS202208"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2026,2,17]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Endoplasmic reticulum (ER) stress-related mucin depletion could be involved in the pathogenesis of ulcerative colitis (UC).\n                      <jats:italic toggle=\"yes\">Akkermansia muciniphila (A. muciniphila<\/jats:italic>\n                      ) uses mucin as its sole energy source and shows potential in the treatment of colitis. However, the effects and underlying mechanisms of\n                      <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                      on colonic epithelial ER stress in colitis are largely unknown. Colitis was induced by adding 2.5% dextran sulfate sodium (DSS) in drinking water. Mice were orally administered\n                      <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                      (3*10\n                      <jats:sup>^<\/jats:sup>\n                      7, 3*10\n                      <jats:sup>^<\/jats:sup>\n                      8 cfu\/day) once daily for 10 days during DSS intervention. Ultra high performance liquid chromatography q-exactive orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap-HRMS)-based metabolomic analyses were performed on feces. 16S rRNA sequencing was used to quantify and characterize the gut microbiota of mice. Metabolomic analysis showed that P-hydroxyphenyl acetic acid (p-HPAA), the metabolite with the highest variable importance in projection (VIP) score that was elevated by\n                      <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                      , was negatively correlated with acetic acid levels and exhibited a potential inhibitory effect on ER stress. Additionally,\n                      <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                      supplementation decreases the abundance of\n                      <jats:italic toggle=\"yes\">Parasutterella,<\/jats:italic>\n                      a genus implicated in bile acid homeostasis. By restoring the levels of deoxycholic (DCA) and ursodeoxycholic acid (UDCA),\n                      <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                      administration normalized the bile acid pool size and composition altered by colitis.\n                      <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                      supplementation protected colon shortening and histological injury in wild-type (WT) mice, but not in farnesoid X receptor-null (FXR\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      ) mice. Mechanistically, our results demonstrate that\n                      <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                      alleviates DSS-induced colitis by targeting inositol requiring enzyme 1\u03b1(IRE1\u03b1) and unspliced XBP1 (XBP1u) within the ER stress pathway, with the regulation of XBP1u being FXR-dependent. Supplementation with\n                      <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                      at appropriate doses may, thus, offer a promising therapeutic strategy for Ulcerative colitis (UC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>IMPORTANCE<\/jats:title>\n                    <jats:p>\n                      UC is a chronic inflammatory disease in which inflammation begins in the rectum and extends proximally throughout the colon.\n                      <jats:italic toggle=\"yes\">A.muciniphia<\/jats:italic>\n                      is significantly reduced in UC patients and shows promise as a next-generation probiotic. However, the mechanisms behind its protective effects are not fully understood. Our study reveals that\n                      <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                      alleviates experimental colitis by reshaping the gut microbiome and correcting imbalances in bile acid metabolism. Crucially, we identify a novel mechanism where\n                      <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                      acts through the host bile acid receptor FXR to suppress a specific ER stress pathway (XBP1u) in colon cells, thereby helping to restore the intestinal barrier. These findings provide a scientific basis for using\n                      <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                      as a targeted therapeutic strategy for UC.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/msystems.01589-25","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:01:01Z","timestamp":1767013261000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["<i>Akkermansia muciniphila<\/i>\n                    alleviates experimental colitis through FXR-mediated repression of unspliced XBP1"],"prefix":"10.1128","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7945-0576","authenticated-orcid":true,"given":"Fan","family":"Bu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"name":"Jiangsu Province Hospital of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/03k14e164","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Colorectal Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College","place":["Hangzhou, China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqing","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"name":"Jiangsu Province Hospital of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"No.1 Clinical Medical College, Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Basic Pharmacology, The Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Song","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"name":"Jiangsu Province Hospital of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"No.1 Clinical Medical College, Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Basic Pharmacology, The Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhai","family":"He","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"name":"Jiangsu Province Hospital of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"No.1 Clinical Medical College, Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Lu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"name":"Jiangsu Province Hospital of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"No.1 Clinical Medical College, Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Yuan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"name":"Jiangsu Province Hospital of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"No.1 Clinical Medical College, Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"name":"Jiangsu Province Hospital of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"No.1 Clinical Medical College, Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Jiang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"name":"Jiangsu Province Hospital of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"No.1 Clinical Medical College, Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"name":"Jiangsu Province Hospital of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"No.1 Clinical Medical College, Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"name":"Jiangsu Province Hospital of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"No.1 Clinical Medical College, Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"name":"Jiangsu Province Hospital of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"No.1 Clinical Medical College, Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2510-4054","authenticated-orcid":false,"given":"Yugen","family":"Chen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"name":"Jiangsu Province Hospital of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"No.1 Clinical Medical College, Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6251-4996","authenticated-orcid":false,"given":"Qiong","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"name":"Jiangsu Province Hospital of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"No.1 Clinical Medical College, Nanjing University of Chinese Medicine","place":["Nanjing, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/04523zj19","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Basic Pharmacology, The Affiliated Hospital of Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx008"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0205-x"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-052919-120048"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.02873-0"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219451110"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e31827fec6d"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2016.1190073"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i25.4548"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-00070-7"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050054"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17020193"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000238"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2522-3_15"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-019-0805-2"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2018.12.002"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.629798"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06622-7"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.05.005"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-020-10976-3"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1927633"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.07.068"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13124343"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14570"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.694323"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29815"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20753"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.723856"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1987779"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00009.2015"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.18.01379"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01192"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.016083"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-019-0364-5"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30219"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319745"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.04050-14"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20190716"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00122.2020"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118411"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-05473-y"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-023-01722-8"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.01.021"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0007502020"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2015.0094"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.10.014"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-023-01053-z"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147839"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2016.44"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1763292"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.153935"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106396"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.5582\/ddt.2015.01008"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-56685-z"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025589"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-56685-z"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5453.664"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9485"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1159\/000338121"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9112495"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.51804"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2022.100289"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156456"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2022.0117"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0495-2"}],"container-title":["mSystems"],"original-title":[],"contributor":[{"given":"Yi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]}],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.01589-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msystems.01589-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:01:55Z","timestamp":1771336915000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msystems.01589-25"}},"subtitle":[],"editor":[{"given":"Batbileg","family":"Bor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,2,17]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,17]]}},"alternative-id":["10.1128\/msystems.01589-25"],"URL":"https:\/\/doi.org\/10.1128\/msystems.01589-25","relation":{},"ISSN":["2379-5077"],"issn-type":[{"value":"2379-5077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,17]]},"assertion":[{"value":"2025-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01589-25"}}