{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:29:03Z","timestamp":1792459743904,"version":"4.5.0"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"The President Foundation of Nanfang Hospital, Southern Medical University","award":["2024A001, 2021B003"],"award-info":[{"award-number":["2024A001, 2021B003"]}]},{"name":"National Natural Science Foundation of China Regional Joint Key Project","award":["U22A20365"],"award-info":[{"award-number":["U22A20365"]}]},{"name":"National Natural Science Foundation of China Interdisciplinary Project","award":["T2341019"],"award-info":[{"award-number":["T2341019"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012429"],"award-info":[{"award-number":["2023A1515012429"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Scientific and Technological Project of Guangzhou Municipal Health Commision","award":["20252D003"],"award-info":[{"award-number":["20252D003"]}]},{"name":"Key Reaearch and Development Program of Guangzhou Science and Technology Bureau","award":["2024B03J1343"],"award-info":[{"award-number":["2024B03J1343"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2026,7,21]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Sepsis-induced acute kidney injury (SAKI) remains a major contributor to mortality, yet the impact of environmental factors\u2014particularly humidity\u2014on disease progression is poorly understood. Here, we investigated how short-term high-humidity exposure shapes host susceptibility to SAKI and explored the underlying microbiota- and metabolite-mediated mechanisms. Mice pre-exposed to high humidity exhibited markedly attenuated renal injury and improved survival following cecal ligation and puncture (CLP). Notably, this protective effect persisted after bacterial depletion, but was abolished by amphotericin B treatment, indicating a fungus-dependent mechanism. Internal transcribed spacer sequencing and microbiota manipulation experiments identified\n                      <jats:italic toggle=\"yes\">Meyerozyma caribbica<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">M. caribbica<\/jats:italic>\n                      ) as a humidity-enriched commensal fungus essential for renal protection. Metabolomic profiling further revealed syringic acid (SA) as a key\n                      <jats:italic toggle=\"yes\">M. caribbica<\/jats:italic>\n                      \u2013derived metabolite responsible for the observed benefits. SA suppressed MAPK and NF-\u03baB activation, reduced inflammatory cytokine release, and inhibited macrophage pyroptosis\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      . Together, these findings demonstrate that high humidity confers protection against SAKI through an\n                      <jats:italic toggle=\"yes\">M. caribbica<\/jats:italic>\n                      \u2013SA axis that modulates macrophage inflammation and pyroptosis, highlighting a previously unrecognized environment\u2013microbiota\u2013host interaction in septic immunoregulation.\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        Sepsis outcomes are traditionally attributed to host immunity and microbial infection, whereas environmental influences remain largely overlooked. This study reveals that short-term environmental humidity profoundly shapes septic kidney injury through a commensal fungus\u2013derived metabolite, establishing\n                        <jats:italic toggle=\"yes\">M. caribbica<\/jats:italic>\n                        and its product syringic acid as key mediators of renoprotection. These findings challenge the conventional bacteria-centered view of sepsis\u2013microbiota interactions and uncover humidity-driven mycobiota remodeling as a critical regulator of immune responses. By defining an environment\u2013fungus\u2013host axis that mitigates macrophage inflammation and pyroptosis, this work provides a conceptual framework for leveraging environmental modulation or fungal metabolites as novel therapeutic strategies for sepsis.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/msystems.01716-25","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:01:46Z","timestamp":1781528506000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["High humidity reprograms the gut mycobiome to promote\n                    <i>Meyerozyma caribbica<\/i>\n                    \u2013derived syringic acid and attenuate sepsis-induced acute kidney injury"],"prefix":"10.1128","volume":"11","author":[{"given":"Shumin","family":"Cai","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01vjw4z39","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Health Management, Nanfang Hospital, Southern Medical University","place":["Guangzhou, China"]},{"id":[{"id":"https:\/\/ror.org\/01vjw4z39","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiheng","family":"Guo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01vjw4z39","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Traditional Chinese Medicine, Southern Medical University","place":["Guangzhou, 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