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MicroRNAs are conserved, non-coding RNA molecules that regulate gene expression and are detected in microbial infections. This study aims to characterize the microRNA expression kinetics in the mandibles of C57BL\/6J mice infected with\n                      <jats:italic toggle=\"yes\">F. nucleatum<\/jats:italic>\n                      for 8 and 16 weeks and to identify miRNAs as potential biomarkers using NanoString nCounter miRNA panels. Mice were divided into four groups: 8 weeks of infection, 16 weeks of infection, and their respective sham infection.\n                      <jats:italic toggle=\"yes\">F. nucleatum<\/jats:italic>\n                      -infected mice showed 100% bacterial colonization on the gingival surface, along with a significant increase in alveolar bone resorption (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001) and intravascular dissemination to the heart, indicating its invasive potential. Out of 577 miRNAs analyzed, seven miRNAs were upregulated, and two miRNAs were downregulated in the 8 weeks of infection group. In the 16 weeks of infection group, seven miRNAs were upregulated while 13 miRNAs were downregulated. Notably, miR-205, miR-210, and miR-199a-3p were differentially expressed at 8 weeks as well as miR-28 at 16 weeks and have been previously reported in human periodontitis. The 13 miRNAs induced by\n                      <jats:italic toggle=\"yes\">F. nucleatum<\/jats:italic>\n                      (e.g., miR-361-5p) are linked to 13 multiple malignancies. In addition, miR-126-5p has been identified as a potential biomarker for patients with PD and cardiovascular disease. These results indicate that\n                      <jats:italic toggle=\"yes\">F. nucleatum<\/jats:italic>\n                      induces several PD-related miRNAs and links them to systemic comorbidities. Furthermore, this study revealed\n                      <jats:italic toggle=\"yes\">F. nucleatum<\/jats:italic>\n                      induction of 14 oncogenic miRNAs, and specifically, 12 miRNAs were linked with CRC.\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        Our study investigated oral commensal\n                        <jats:italic toggle=\"yes\">Fusobacterium nucleatum<\/jats:italic>\n                        , a critical bacterium associated with gum disease, adverse pregnancy outcomes, and enriched several tumors, including colorectal cancer (CRC). Recently, microRNAs have emerged as critical players in the interactions between host and microbes, and many host functions have been reported to be regulated by miRNAs during infection.\n                        <jats:italic toggle=\"yes\">F. nucleatum<\/jats:italic>\n                        oral infection in mice induced gum disease, disseminated to the heart, lungs, and several miRNAs. Elevated miR-361 expression was linked to multiple cancers. In addition, miR-126-5p expression has been reported as a potential biomarker in patients with periodontitis and coronary artery disease, indicating\n                        <jats:italic toggle=\"yes\">F. nucleatum<\/jats:italic>\n                        \u2019s virulence potential. The 13 miRNAs induced by\n                        <jats:italic toggle=\"yes\">F. nucleatum<\/jats:italic>\n                        are linked to 13 multiple malignancies, including CRC. These results indicate that\n                        <jats:italic toggle=\"yes\">F. nucleatum<\/jats:italic>\n                        acts as a potent cancer-causing bacterium. This study opens new avenues for exploring\n                        <jats:italic toggle=\"yes\">F. nucleatum<\/jats:italic>\n                        \u2019s role in gum disease and its link with cancer.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/msystems.01732-24","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T09:00:14Z","timestamp":1750842014000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Exploring the complex interplay between oral\n                    <i>Fusobacterium nucleatum<\/i>\n                    infection, periodontitis, and robust microRNA induction, including multiple known oncogenic miRNAs"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2769-8619","authenticated-orcid":false,"given":"Syam","family":"Jeepipalli","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Periodontology, College of Dentistry, University of Florida","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravindraja","family":"C","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Periodontology, College of Dentistry, University of Florida","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Duncan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Community Dentistry and Behavioral Science, College of Dentistry, University of Florida","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. 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