{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:59:12Z","timestamp":1785405552516,"version":"3.56.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                      is difficult to treat owing to its intrinsic and acquired resistance to antibiotics, particularly vancomycin. Vancomycin-resistant\n                      <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                      is an important cause of bloodstream infections in healthcare settings with limited treatment options. This study aimed to analyze the risk factors for vancomycin-resistant\n                      <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                      bloodstream infection. This retrospective analysis of data from the Munich Multicentric Enterococci Cohort analyzed 200 episodes of nonrecurrent vancomycin-susceptible\n                      <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                      bloodstream infection and 196 episodes of nonrecurrent vancomycin-resistant\n                      <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                      bloodstream infection from six hospitals in Munich, Germany, between 2010 and 2019. Logistic regression was used to identify risk factors for vancomycin-resistant\n                      <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                      bloodstream infection. In the unadjusted analysis, the risk factors for vancomycin-resistant\n                      <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                      bloodstream infection included the length of hospital stay, previous treatment with vancomycin or linezolid, and solid organ transplantation. In the multivariable analysis, prior treatment with vancomycin and solid organ transplantation were independent risk factors for vancomycin-resistant\n                      <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                      bloodstream infection. Vancomycin resistance was not significantly associated with the severity of underlying diseases. This study identified prior vancomycin treatment and solid organ transplantation as key independent risk factors for vancomycin-resistant\n                      <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                      bloodstream infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>IMPORTANCE<\/jats:title>\n                    <jats:p>\n                      Vancomycin-resistant\n                      <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                      is a growing threat in healthcare settings, challenging the management of enterococcal infections. This study identified prior treatment with vancomycin and solid organ transplantation as risk factors for vancomycin-resistant\n                      <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                      bloodstream infections. Based on the analysis of five disease severity scores for acute and chronic illness, the severity of underlying diseases could not be demonstrated to be a risk factor for the occurrence of vancomycin resistance in\n                      <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                      bloodstream infections.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.00052-25","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T09:01:23Z","timestamp":1749114083000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Risk factors for vancomycin resistance in patients with\n                    <i>Enterococcus faecium<\/i>\n                    bloodstream infections: an analysis of the Munich Multicentric Enterococci Cohort"],"prefix":"10.1128","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5184-8154","authenticated-orcid":true,"given":"Laura","family":"Wagner","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02kkvpp62","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine II, TUM School of Medicine and Health, TUM University Hospital, Technical University of Munich","place":["Munich, Germany"]},{"name":"German Centre for Infection Research (DZIF), partner site Munich","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Wurst","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02kkvpp62","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine II, TUM School of Medicine and Health, TUM University Hospital, Technical University of Munich","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Erber","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02kkvpp62","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine II, TUM School of Medicine and Health, TUM University Hospital, Technical University of Munich","place":["Munich, Germany"]},{"name":"German Centre for Infection Research (DZIF), partner site Munich","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Bachfischer","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02kkvpp62","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine II, TUM School of Medicine and Health, TUM University Hospital, Technical University of Munich","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Haller","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007rawr89","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of AI and Informatics in Medicine, TUM School of Medicine and Health, Technical University of Munich","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Gleich","sequence":"additional","affiliation":[{"name":"Public Health Service, City of Munich","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Dichtl","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05591te55","id-type":"ROR","asserted-by":"publisher"}],"name":"Max von Pettenkofer Institute for Hygiene und Medical Microbiology, Faculty of Medicine, Ludwig Maximilian University of Munich","place":["Munich, Germany"]},{"id":[{"id":"https:\/\/ror.org\/02n0bts35","id-type":"ROR","asserted-by":"publisher"}],"name":"Diagnostic and Research Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz","place":["Graz, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland M.","family":"Schmid","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02kkvpp62","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine II, TUM School of Medicine and Health, TUM University Hospital, Technical University of Munich","place":["Munich, Germany"]},{"name":"German Centre for Infection Research (DZIF), partner site Munich","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Triebelhorn","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02kkvpp62","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine II, TUM School of Medicine and Health, TUM University Hospital, Technical University of Munich","place":["Munich, Germany"]},{"name":"German Centre for Infection Research (DZIF), partner site Munich","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Voit","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02kkvpp62","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine II, TUM School of Medicine and Health, TUM University Hospital, Technical University of Munich","place":["Munich, Germany"]},{"name":"German Centre for Infection Research (DZIF), partner site Munich","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Seybold","sequence":"additional","affiliation":[{"name":"German Centre for Infection Research (DZIF), partner site Munich","place":["Munich, Germany"]},{"id":[{"id":"https:\/\/ror.org\/05591te55","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases, Department of Medicine IV, Hospital of the Ludwig Maximilian University of Munich","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk H.","family":"Busch","sequence":"additional","affiliation":[{"name":"German Centre for Infection Research (DZIF), partner site Munich","place":["Munich, Germany"]},{"id":[{"id":"https:\/\/ror.org\/007rawr89","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Medical Microbiology, Immunology and Hygiene, TUM School of Medicine and Health, Technical University of Munich","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick C.","family":"R\u00e4mer","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03pfshj32","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Hospital Hygiene and Infection Control, Munich Municipal Hospital Group","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph D.","family":"Spinner","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02kkvpp62","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine II, TUM School of Medicine and Health, TUM University Hospital, Technical University of Munich","place":["Munich, Germany"]},{"name":"German Centre for Infection Research (DZIF), partner site Munich","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Schneider","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02kkvpp62","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine II, TUM School of Medicine and Health, TUM University Hospital, Technical University of Munich","place":["Munich, Germany"]},{"name":"German Centre for Infection Research (DZIF), partner site Munich","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Rothe","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007rawr89","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Medical Microbiology, Immunology and Hygiene, TUM School of Medicine and Health, Technical University of Munich","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_5_2_2","unstructured":"Control ECfDPa. 2023. Antimicrobial resistance surveillance in Europe 2023\u20132021 data"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.GPP3-0053-2018"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/342904"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2014.3"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.00911.x"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03591.x"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.4.993"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0732-8893(99)00136-4"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usaa229"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ560"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12132"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02585-23"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/520311"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2018.05.003"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2020.12.005"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-018-0419-9"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.05.016"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2013.0725"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2022.07.001"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11091228"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2016.12.020"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2010.11.005"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2011.04.004"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.00052-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.00052-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T09:05:37Z","timestamp":1751360737000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.00052-25"}},"subtitle":[],"editor":[{"given":"Siu-Kei","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1128\/spectrum.00052-25"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.00052-25","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00052-25"}}