{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:56:07Z","timestamp":1785426967459,"version":"3.56.0"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["GH002259"],"award-info":[{"award-number":["GH002259"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Candida auris<\/jats:italic>\n                      is a multidrug-resistant yeast causing invasive infection and healthcare-associated outbreaks globally. We aimed to estimate the extent of\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      colonization and infection among neonates in selected neonatal intensive care units (NICUs) in Dhaka City. We conducted a prospective study from August 2021 to September 2022. Skin swabs and blood samples were collected from NICU patients.\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      was identified using CHROMagar and VITEK-2. Patient characteristics and healthcare histories were recorded. Of 374 patients enrolled, 32 (9%) were colonized with\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      , and one (0.3%) developed a bloodstream infection (BSI). The median age of the enrolled patients was 4 days (IQR: 2\u20138); 60% were male. Among the colonized patients, 44% (14\/32) were colonized at enrollment, and 56% (18\/32) became colonized after enrollment, occurring 3\u201319 days after admission. Of patients colonized on admission, five (36%) were admitted from the obstetric ward, eight (57%) from another hospital, and one (7%) from home. Seven (22%) of the 32 colonized patients, including the one with BSI, died. All deaths occurred in public hospitals. Three (9%)\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      isolates demonstrated resistance to two antifungal drug classes. Our findings suggest frequent transmission of\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      within the NICU, as demonstrated by more than half of the patients acquiring colonization after 48 h of admission. The high rate of\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      transmission underscores the critical need for improved patient detection and robust infection prevention and control measures. Further investigation into\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      transmission dynamics is crucial to inform prevention strategies.\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        <jats:italic toggle=\"yes\">Candida auris<\/jats:italic>\n                        is a serious fungal pathogen that is resistant to multiple antifungal medications. It is a significant concern in healthcare settings, particularly in neonatal intensive care units (NICUs) where vulnerable newborns are at increased risk of infection. This may be a serious public health issue due to its high mortality, limited treatment options, risk of transmission, and strain diversity.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.00129-25","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:00:31Z","timestamp":1760101231000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["<i>Candida auris<\/i>\n                    colonization among critically ill neonatal intensive care unit patients in Dhaka, Bangladesh"],"prefix":"10.1128","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4277-8318","authenticated-orcid":true,"given":"Fahmida","family":"Chowdhury","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04vsvr128","id-type":"ROR","asserted-by":"publisher"}],"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)","place":["Dhaka, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syeda","family":"Mah-E-Muneer","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04vsvr128","id-type":"ROR","asserted-by":"publisher"}],"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)","place":["Dhaka, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanzida","family":"Khan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04vsvr128","id-type":"ROR","asserted-by":"publisher"}],"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)","place":["Dhaka, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Jordan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00qzjvm58","id-type":"ROR","asserted-by":"publisher"}],"name":"Mycotic Diseases Branch, Centers for Diseases Control and Prevention","place":["Atlanta, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0907-7875","authenticated-orcid":false,"given":"Gazi Md.","family":"Salahuddin Mamun","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04vsvr128","id-type":"ROR","asserted-by":"publisher"}],"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)","place":["Dhaka, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4383-5994","authenticated-orcid":true,"given":"Shawn R.","family":"Lockhart","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00qzjvm58","id-type":"ROR","asserted-by":"publisher"}],"name":"Mycotic Diseases Branch, Centers for Diseases Control and Prevention","place":["Atlanta, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakir Hossain","family":"Habib","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology, Disease Control & Research (IEDCR)","place":["Dhaka, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aninda","family":"Rahman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05xkzd182","id-type":"ROR","asserted-by":"publisher"}],"name":"Communicable Disease Control, DGHS","place":["Dhaka, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Hossain","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04vsvr128","id-type":"ROR","asserted-by":"publisher"}],"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)","place":["Dhaka, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakiul","family":"Hassan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04vsvr128","id-type":"ROR","asserted-by":"publisher"}],"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)","place":["Dhaka, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahmina","family":"Shirin","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology, Disease Control & Research (IEDCR)","place":["Dhaka, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajeda","family":"Prema","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04vsvr128","id-type":"ROR","asserted-by":"publisher"}],"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)","place":["Dhaka, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9729-5233","authenticated-orcid":true,"given":"Md. 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Tracking Candida auris. CDC. Atlanta GA USA. Available from: https:\/\/www.cdc.gov\/fungal\/candida-auris\/tracking-c-auris.html#world. Retrieved 11 Dec 2019."},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011268"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001318"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myy054"},{"key":"e_1_3_5_9_2","first-page":"1","volume-title":"The global challenge of Candida auris in the intensive care unit","author":"Cortegiani A","year":"2019","unstructured":"Cortegiani A, Misseri G, Giarratano A, Bassetti M, Eyre D. 2019. The global challenge of Candida auris in the intensive care unit, p 1\u20133. 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