{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:19:10Z","timestamp":1785403150469,"version":"3.56.0"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100017513","name":"Sichuan Association for Science and Technology","doi-asserted-by":"publisher","award":["2020YFS0005"],"award-info":[{"award-number":["2020YFS0005"]}],"id":[{"id":"10.13039\/100017513","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017368","name":"International S and T Cooperation Program of Sichuan Province","doi-asserted-by":"publisher","award":["2023YFH0081"],"award-info":[{"award-number":["2023YFH0081"]}],"id":[{"id":"10.13039\/100017368","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2025,6,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      The 2019 coronavirus disease (COVID-19) pandemic has changed the characteristics of many diseases. It remains unclear whether idiopathic inflammatory myopathies (IIMs) exhibit distinct phenotypes in the context of COVID-19. This retrospective study analyzed patients with IIMs admitted to West China Hospital from January 2022 to December 2023. Among them, 171 had a history of COVID-19 (prior COVID-19 [PC]), while 121 did not (no prior COVID-19 [NPC]). Medical histories, lab tests, and echocardiography data were compared. The PC group exhibited a greater incidence of cardiac damage, including a greater proportion of cardiac injury (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.016), clinical diagnosis of myocarditis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02), palpitation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.031), and Myositis Activity Assessment Visual Analog Scale\/Myositis Intention-to-Treat Activity Index cardiovascular involvement scores (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), and elevated levels of myoglobin (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03), creatinine kinase MB (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.015), cardiac troponin T (\n                      <jats:italic toggle=\"yes\">P =<\/jats:italic>\n                      0.011), N-terminal pro-B-type natriuretic peptide (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.028), lactate dehydrogenase (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.033), and hydroxybutyrate dehydrogenase (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.019). Echocardiographic analysis revealed a greater diameter of the left atrium (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.040), left ventricle (\n                      <jats:italic toggle=\"yes\">P =<\/jats:italic>\n                      0.013), greater end-diastolic dimension (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.042), and greater end-diastolic volume (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.036) in the PC group than in the NPC group. Transcriptional data analysis based on public databases indicated that various mechanisms, including collagen matrix proliferation, calcium ion pathway regulation, oxidative stress, cell proliferation, and inflammatory molecules, collectively contribute to the pathogenesis of myocardial damage in patients with IIMs and COVID-19. The study serves as a crucial reminder for clinicians to remain vigilant regarding the enduring cardiovascular consequences associated with IIMs after COVID-19.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>IMPORTANCE<\/jats:title>\n                    <jats:p>This study systematically analyzed the clinical features, laboratory test results, and echocardiographic findings of patients with IIMs, comparing those with and without a history of COVID-19 infection. The analysis revealed significant alterations in the clinical manifestations of IIM patients after COVID-19, particularly in relation to cardiac involvement. Our findings highlight the crucial importance for clinicians to maintain vigilance concerning the potential long-term cardiovascular sequelae associated with IIMs in post-COVID-19 patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.00134-25","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T09:00:12Z","timestamp":1747299612000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Investigating the profile of patients with idiopathic inflammatory myopathies in the post-COVID-19 period"],"prefix":"10.1128","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5875-0339","authenticated-orcid":true,"given":"Lu","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University","place":["Chengdu, 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Rheumatology and Immunology, Laboratory of Rheumatology and Immunology West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03gxy9f87","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Respiratory and Critical Care Medicine, Chengdu First People\u2019s Hospital","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Ye","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04ewct822","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Basic Medicine, Tianfu College, Southwestern University of Finance and Economics","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-ping","family":"Liang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/011ashp19","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Rheumatology and Immunology, Laboratory of Rheumatology and Immunology West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/011ashp19","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Rheumatology and Immunology, Laboratory of Rheumatology and Immunology West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-ying","family":"Huang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/011ashp19","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of 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during COVID-19 pandemic (A Case Series): is there a cause effect relationship?","volume":"68","author":"Gokhale Y","year":"2020","unstructured":"Gokhale Y, Patankar A, Holla U, Shilke M, Kalekar L, Karnik ND, Bidichandani K, Baveja S, Joshi A. 2020. 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