{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:40:16Z","timestamp":1792510816979,"version":"4.5.0"},"reference-count":91,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GM148752"],"award-info":[{"award-number":["T32GM148752"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 AI171403"],"award-info":[{"award-number":["U19 AI171403"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 109022"],"award-info":[{"award-number":["R01 109022"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI161363"],"award-info":[{"award-number":["R01 AI161363"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["75N93021C00014"],"award-info":[{"award-number":["75N93021C00014"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 AI135972"],"award-info":[{"award-number":["U19 AI135972"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001448","name":"Alpha-1 Foundation","doi-asserted-by":"publisher","award":["U19 AI142733"],"award-info":[{"award-number":["U19 AI142733"]}],"id":[{"id":"10.13039\/100001448","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      The continuous emergence of variants of concern (VoCs) represents a significant challenge to effectively control severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although FDA-approved vaccines and antivirals have been successfully developed and implemented for the prophylactic and therapeutic intervention of SARS-CoV-2 infection, recent VoCs could escape protection garnered by previous vaccine and antiviral approaches. Determining the efficacy of prophylactics and\/or therapeutics against recent VoCs will assist in efficiently controlling currently circulating SARS-CoV-2 strains. We used our previously described bacterial artificial chromosome-based reverse genetics approach for Omicron BA.5 to generate a recombinant SARS-CoV-2 BA.5 encoding a fusion of ZsGreen to Nanoluciferase (rBA.5 ZsG-Nluc) from the locus of the viral nucleocapsid (N) protein separated by the porcine teschovirus-1 2A proteolytic cleavage site. The rBA.5 ZsG-Nluc replicates to levels comparable to recombinant BA.5 wild type (rBA.5 WT) and expresses high levels of ZsG and Nluc in cultured cells. This facilitates tracking viral infection and the identification of antivirals and neutralizing antibodies with EC\n                      <jats:sub>50<\/jats:sub>\n                      and NT\n                      <jats:sub>50<\/jats:sub>\n                      values, respectively, similar to those obtained with rBA.5 WT. Importantly, in Keratin-18 human angiotensin-converting enzyme-2 mice, rBA.5 ZsG-Nluc retains the same pathogenicity and ability to replicate in the lungs of infected mice as rBA.5 WT. Using rBA.5 ZsG-Nluc, we detected Nluc activity systemically and Nluc and ZsG expression in the lungs of infected mice using an\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      imaging system. Our results demonstrate the feasibility of using rBA.5 ZsG-Nluc to track viral infections and identify prophylactics and therapeutics against recent SARS-CoV-2 VoCs\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">ex vivo<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      .\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative virus of the coronavirus disease 2019 pandemic, is continually evolving to escape immunity acquired by previous natural infections or vaccinations. Moreover, recent SARS-CoV-2 variants of concern (VoCs) have acquired antiviral-resistant mutations to FDA-approved drugs. The emergence of these VoCs highlights the importance of identifying new prophylactics and therapeutics against currently circulating SARS-CoV-2 strains. We generated a recombinant bireporter Omicron BA.5 SARS-CoV-2 (rBA.5 ZsG-Nluc) that expresses reporter proteins, which are useful for cellular and whole animal studies, and has similar viral replication and pathogenicity to a wild-type recombinant Omicron BA.5 SARS-CoV-2. In Keratin-18 human angiotensin-converting enzyme-2 mice, rBA.5 ZsG-Nluc infection can be tracked systemically or in the lungs of infected mice using an\n                        <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                        imaging system. We establish a proof-of-concept platform of rBA.5 ZsG-Nluc in combination with an ancestral SARS-CoV-2 strain expressing mCherry to simultaneously identify antivirals and neutralizing antibodies against original and recent SARS-CoV-2 strains.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.00217-26","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:01:47Z","timestamp":1789045307000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["A bireporter recombinant SARS-CoV-2 Omicron BA.5 for\n                    <i>in vitro<\/i>\n                    and\n                    <i>in vivo<\/i>\n                    studies"],"prefix":"10.1128","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2540-8382","authenticated-orcid":false,"given":"Esteban M.","family":"Castro","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yr0pg70","id-type":"ROR","asserted-by":"publisher"}],"name":"Texas Biomedical Research Institute","place":["San Antonio, USA"]},{"name":"Graduate School of Biomedical Sciences, Long School of Medicine at University of Texas Health & Science Center","place":["San Antonio, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramya S.","family":"Barre","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yr0pg70","id-type":"ROR","asserted-by":"publisher"}],"name":"Texas Biomedical Research Institute","place":["San Antonio, USA"]},{"name":"Graduate School of Biomedical Sciences, Long School of Medicine at University of Texas Health & Science Center","place":["San Antonio, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1934-9494","authenticated-orcid":true,"given":"Chengjin","family":"Ye","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yr0pg70","id-type":"ROR","asserted-by":"publisher"}],"name":"Texas Biomedical Research Institute","place":["San Antonio, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Imbiakha","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05bnh6r87","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology, College of Agriculture and Life Sciences, Cornell University","place":["Ithaca, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrzad","family":"Ezzatpour","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05bnh6r87","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology, College of Agriculture and Life Sciences, Cornell University","place":["Ithaca, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasija","family":"Cupic","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04a9tmd77","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai","place":["New York, USA"]},{"id":[{"id":"https:\/\/ror.org\/04a9tmd77","id-type":"ROR","asserted-by":"publisher"}],"name":"Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Walter","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/008s83205","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology, University of Alabama at Birmingham","place":["Birmingham, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8069-0272","authenticated-orcid":true,"given":"James J.","family":"Kobie","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/008s83205","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham","place":["Birmingham, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"K. Plemper","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03qt6ba18","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Translational Antiviral Research, Institute for Biomedical Sciences, Georgia State University","place":["Atlanta, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6551-1827","authenticated-orcid":true,"given":"Adolfo","family":"Garc\u00eda-Sastre","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04a9tmd77","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai","place":["New York, USA"]},{"id":[{"id":"https:\/\/ror.org\/04a9tmd77","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai","place":["New York, USA"]},{"id":[{"id":"https:\/\/ror.org\/04a9tmd77","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai","place":["New York, USA"]},{"id":[{"id":"https:\/\/ror.org\/04a9tmd77","id-type":"ROR","asserted-by":"publisher"}],"name":"Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai","place":["New York, USA"]},{"id":[{"id":"https:\/\/ror.org\/04a9tmd77","id-type":"ROR","asserted-by":"publisher"}],"name":"Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai","place":["New York, USA"]},{"id":[{"id":"https:\/\/ror.org\/04a9tmd77","id-type":"ROR","asserted-by":"publisher"}],"name":"Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Elsayed","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yr0pg70","id-type":"ROR","asserted-by":"publisher"}],"name":"Texas Biomedical Research Institute","place":["San Antonio, USA"]},{"id":[{"id":"https:\/\/ror.org\/02n85j827","id-type":"ROR","asserted-by":"publisher"}],"name":"Center of Scientific Excellence for Influenza Viruses, National Research Centre","place":["Giza, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6879-8360","authenticated-orcid":true,"given":"Hector C.","family":"Aguilar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05bnh6r87","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology, College of Agriculture and Life Sciences, Cornell University","place":["Ithaca, USA"]},{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of California","place":["Los Angeles, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7084-0804","authenticated-orcid":true,"given":"Luis","family":"Martinez-Sobrido","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yr0pg70","id-type":"ROR","asserted-by":"publisher"}],"name":"Texas Biomedical Research Institute","place":["San Antonio, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-00468-6"},{"key":"e_1_3_5_3_2","unstructured":"WHO. 2025. World Health Organization 2023 Data. More COVID-19 data from WHO and partner agencies. Available from: https:\/\/data.who.int\/dashboards\/covid19\/more-resources. Retrieved 25 Nov 2025."},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2022.2027160"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2107808"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01143-7"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32396-9"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46490-7"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27927"},{"key":"e_1_3_5_10_2","unstructured":"Our World in Data. 2025. Cumulative Confirmed COVID-19 Deaths vs. Cases Jan 4 2025 to Dec 21 2025. Available from: https:\/\/ourworldindata.org\/grapher\/covid-19-cumulative-confirmed-cases-vs-confirmed-deaths?tab=table&time=2025-01-04..latest&tableFilter=continents. Retrieved 12 Jan 2025."},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/v13040628"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2023.09.021"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00905-24"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16662"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2022.105252"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.3c00538"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51924-3"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade8778"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.35431"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02379-22"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01126-21"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","unstructured":"Ma Y Ye C Khalil AM Mahmoud SH Sobolik EB Greninger AL Castro E Jackson N Bayoumi M Plemper RK Martinez-Sobrido L. 2025 A luminescent attenuated SARS-CoV-2 for the identification and validation of drug-resistant mutants. bioRxiv. doi:10.1101\/2025.05.09.653029","DOI":"10.1101\/2025.05.09.653029"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.04.004"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00331"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/v14092017"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.3791\/63127-v"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80451-6"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.2310\/7290.2013.00062"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb3002478"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2111593118"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.09.018"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.884"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/v16020184"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37826-w"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00809-7"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44298-024-00063-z"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010691"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100218"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00964-21"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adj1736"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04856-1"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2013.28.4.288"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","unstructured":"Moghadasi SA Heilmann E Khalil AM Nnabuife C Kearns FL Ye C Moraes SN Costacurta F Esler MA Aihara H von Laer D Martinez-Sobrido L Palzkill T Amaro RE Harris RS. 2022. Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors. bioRxiv:2022.08.07.503099. doi:10.1101\/2022.08.07.503099","DOI":"10.1101\/2022.08.07.503099"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.3390\/v17050722"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00953-23"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(23)00393-2"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02916-22"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100311"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.139042"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098156"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2312-y"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19891-7"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2453-1_18"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38435-3"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2332-7"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1097\/IM9.0000000000000071"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103465"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.105662"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37787-0"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2102775118"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.3390\/v14010055"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2300376120"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39147-4"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101258"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00692-18"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02366-0"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.20960"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-15979-6"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.4161\/rna.8.2.15013"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27009"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103353"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.02077-21"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e20076"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-00536-8"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002982"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04923-x"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04474-x"},{"key":"e_1_3_5_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-61555-x"},{"key":"e_1_3_5_79_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15347"},{"key":"e_1_3_5_80_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.02077-24"},{"key":"e_1_3_5_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-05263-6"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02168-20"},{"key":"e_1_3_5_83_2","doi-asserted-by":"publisher","DOI":"10.3390\/v12060622"},{"key":"e_1_3_5_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2022.08.002"},{"key":"e_1_3_5_85_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpmc.105"},{"key":"e_1_3_5_86_2","doi-asserted-by":"publisher","DOI":"10.21105\/joss.02991"},{"key":"e_1_3_5_87_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw152"},{"key":"e_1_3_5_88_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_3_5_89_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx699"},{"key":"e_1_3_5_90_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks918"},{"key":"e_1_3_5_91_2","doi-asserted-by":"publisher","DOI":"10.1128\/Spectrum.01601-21"},{"key":"e_1_3_5_92_2","doi-asserted-by":"publisher","DOI":"10.3390\/v13040698"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.00217-26","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.00217-26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:51:59Z","timestamp":1792507919000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.00217-26"}},"subtitle":[],"editor":[{"given":"Bindu","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":91,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,6]]}},"alternative-id":["10.1128\/spectrum.00217-26"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.00217-26","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"assertion":[{"value":"2026-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00217-26"}}