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We reached several conclusions: (i) the antimicrobial resistance of pathogens is severe, and some antimicrobial agents represented by polymyxin are optional according to the antimicrobial susceptibility tests; (ii) in the background that the portion of carbapenems resistance in Gram-negative bacteria is increasing, there is no increasing trend for the antimicrobial resistance of carbapenem-resistant Gram-negative bacteria in the 9-year study; (iii) meropenem is the main antimicrobial agent in treatment, and trimethoprim-sulfamethoxazole, tigecycline, polymyxin, and meropenem\/sulbactam are commonly used in the targeted treatment; (iv) the treatment effect was poor and affected by the treatment: timely active antimicrobial agents should be given.<\/jats:p>","DOI":"10.1128\/spectrum.00253-22","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T10:30:53Z","timestamp":1650882653000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Carbapenem-Resistant Gram-Negative Bacteria-Related Healthcare-Associated Ventriculitis and Meningitis: Antimicrobial Resistance of the Pathogens, Treatment, and Outcome"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3938-2160","authenticated-orcid":true,"given":"Yi","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4189-5800","authenticated-orcid":true,"given":"Guangzhi","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3171\/2014.8.JNS132557"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw077"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz050"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw861"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1478"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/1120009X.2019.1623362"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-019-01370-x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03935-14"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz824"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000608"},{"key":"e_1_3_3_12_2","article-title":"Risk of acute kidney injury and Clostridioides difficile infection with piperacillin\/tazobactam, cefepime and meropenem with or without vancomycin","author":"Lee JD","year":"2020","unstructured":"Lee JD, Heintz BH, Mosher HJ, et al. 2020. 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