{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:53:12Z","timestamp":1790661192786,"version":"4.1.0"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T00:00:00Z","timestamp":1635638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T00:00:00Z","timestamp":1635638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["NCATS 1-UH3-HL-141797-01"],"award-info":[{"award-number":["NCATS 1-UH3-HL-141797-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000185","name":"DOD | Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","award":["HR00111920008"],"award-info":[{"award-number":["HR00111920008"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000185","name":"DOD | Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","award":["HR0011-20-2-0040"],"award-info":[{"award-number":["HR0011-20-2-0040"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2021,10,31]]},"abstract":"<jats:p>The rapid evolution of viruses, such as influenza viruses and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is challenging the use and development of antivirals and vaccines. Studies of within-host viral evolution can contribute to our understanding of the evolutionary and epidemiological factors that shape viral global evolution as well as development of better antivirals and vaccines.<\/jats:p>","DOI":"10.1128\/spectrum.00257-21","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T10:35:53Z","timestamp":1631702153000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":53,"title":["Clinically Relevant Influenza Virus Evolution Reconstituted in a Human Lung Airway-on-a-Chip"],"prefix":"10.1128","volume":"9","author":[{"given":"Longlong","family":"Si","sequence":"first","affiliation":[{"name":"Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqing","family":"Bai","sequence":"additional","affiliation":[{"name":"Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal Yuri","family":"Oh","sequence":"additional","affiliation":[{"name":"Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[{"name":"Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachelle","family":"Prantil-Baun","sequence":"additional","affiliation":[{"name":"Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4319-6520","authenticated-orcid":true,"given":"Donald E.","family":"Ingber","sequence":"additional","affiliation":[{"name":"Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts, USA"},{"name":"Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA"},{"name":"Vascular Biology Program and Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03361-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0002-y"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.146"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188302"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3697"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004249"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2016.10.003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00718-9"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08722"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67338-2"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119115"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","unstructured":"Si L Prantil-Baun R Benam KH Bai H Rodas M Burt M Ingber DE. 2019. Discovery of influenza drug resistance mutations and host therapeutic targets using a human airway chip. bioRxiv. doi:10.1101\/685552.","DOI":"10.1101\/685552"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.119.116640"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06956"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08157"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2017.03.018"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.162"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43030-y"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13087"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1097211"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1121586"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0340-z"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2017.1423152"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1086\/379045"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2020.06.021"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm5014067"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2018.02.007"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01657-16"},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","unstructured":"Sone N Konishi S Igura K Tamai K Ikeo S Korogi Y Kanagaki S Namba T Yamamoto Y Xu Y Takeuchi K Adachi Y Chen-Yoshikawa TF Date H Hagiwara M Tsukita S Hirai T Torisawa YS Gotoh S. 2021. Multicellular modeling of ciliopathy by combining iPS cells and microfluidic airway-on-a-chip technology. Sci Transl Med 13. doi:10.1126\/scitranslmed.abb1298.","DOI":"10.1126\/scitranslmed.abb1298"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","unstructured":"Herland A Maoz BM Das D Somayaji MR Prantil-Baun R Novak R Cronce M Huffstater T Jeanty SSF Ingram M Chalkiadaki A Benson Chou D Marquez S Delahanty A Jalili-Firoozinezhad S Milton Y Sontheimer-Phelps A Swenor B Levy O Parker KK Przekwas A Ingber DE. 2020. Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips. Nat Biomed Eng 4:421\u2013436. doi:10.1038\/s41551-019-0498-9.","DOI":"10.1038\/s41551-019-0498-9"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/Spectrum.00257-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/Spectrum.00257-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T03:39:15Z","timestamp":1646710755000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/Spectrum.00257-21"}},"subtitle":[],"editor":[{"given":"Heba H.","family":"Mostafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,10,31]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,10,31]]}},"alternative-id":["10.1128\/Spectrum.00257-21"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.00257-21","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,31]]},"assertion":[{"value":"2021-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00257-21"}}