{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:56:08Z","timestamp":1789692968140,"version":"4.0.1"},"reference-count":56,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Ni262\/20-1"],"award-info":[{"award-number":["Ni262\/20-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2023,4,13]]},"abstract":"<jats:p>Homeostasis of essential-but-toxic transition metal cations such as Zn(II) and Cu(II)\/Cu(I) is an important contributor to the fitness of environmental bacteria and pathogenic bacteria during their confrontation with an infected host. Highly efficient removal of threatening concentrations of these metals can be achieved by the combined actions of an inner membrane with a transenvelope efflux system, which removes periplasmic ions after their export from the cytoplasm to this compartment.<\/jats:p>","DOI":"10.1128\/spectrum.00291-23","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T10:12:18Z","timestamp":1678788738000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["The Sensory Histidine Kinase CusS of Escherichia coli Senses Periplasmic Copper Ions"],"prefix":"10.1128","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5337-3829","authenticated-orcid":true,"given":"Jeanine","family":"Rismondo","sequence":"first","affiliation":[{"name":"Institute for Biology\/Microbiology, Molecular Microbiology, Martin-Luther-University Halle-Wittenberg, Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Gro\u00dfe","sequence":"additional","affiliation":[{"name":"Institute for Biology\/Microbiology, Molecular Microbiology, Martin-Luther-University Halle-Wittenberg, Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4516-8267","authenticated-orcid":true,"given":"Dietrich H.","family":"Nies","sequence":"additional","affiliation":[{"name":"Institute for Biology\/Microbiology, Molecular Microbiology, Martin-Luther-University Halle-Wittenberg, Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00020-06"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2201204119"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2012.02529.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.20.5864-5871.2000"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104122200"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.13.3804-3812.2003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-147-4-965"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2014.06.001"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.01193-20"},{"key":"e_1_3_2_11_2","first-page":"79","volume-title":"Microbial efflux pumps: current research.","author":"Nies DH","year":"2013","unstructured":"Nies DH. 2013. RND-efflux pumps for metal cations, p 79\u2013122. In Yu EW, Zhang Q, Brown MH (ed), Microbial efflux pumps: current research. Caister Academic Press, Norfolk, UK."},{"key":"e_1_3_2_12_2","first-page":"107","article-title":"The RND superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins","volume":"1","author":"Tseng T-T","year":"1999","unstructured":"Tseng T-T, Gratwick KS, Kollman J, Park D, Nies DH, Goffeau A, Saier MHJ. 1999. The RND superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins. J Mol Microbiol Biotechnol 1:107\u2013125.","journal-title":"J Mol Microbiol Biotechnol"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.37.26065"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09395"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09743"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052710499"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.652"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi050827b"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.22.7815-7817.2004"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5474"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.6.2145-2147.2001"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02842-14"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01357-06"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2022.107883"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b00707"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.4315"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.172.2.1035-1042.1990"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410104200"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13348"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/1758-2229.12389"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2021.12.015"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06792.x"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.1994.tb00112.x"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.14.4492-4498.1993"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.170.6.2879-2883.1988"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00286685"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1039\/c5mt00320b"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1085950"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006508200"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02264.x"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01370-08"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.162.1.328-334.1985"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12123"},{"key":"e_1_3_2_44_2","unstructured":"Nikaido H. 2009. The limitations of LB medium. http:\/\/schaechter.asmblog.org\/schaechter\/2009\/11\/the-limitations-of-lb-medium.html. Accessed 16 November 2012."},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.169.10.4865-4868.1987"},{"key":"e_1_3_2_46_2","volume-title":"Molecular cloning, a laboratory manual","author":"Sambrook J","year":"1989","unstructured":"Sambrook J, Fritsch EF, Maniatis T. 1989. Molecular cloning, a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.","edition":"2"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.120163297"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.22.6871-6879.1997"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.4.1074"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.174.24.8102-8110.1992"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.21.5799-5802.1998"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.171.9.5065-5070.1989"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1039\/c4mt00297k"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01951-12"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00004-16"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/br.36.4.525-557.1972"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.00291-23","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.00291-23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T09:22:46Z","timestamp":1681377766000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.00291-23"}},"subtitle":[],"editor":[{"given":"Beile","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,4,13]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4,13]]}},"alternative-id":["10.1128\/spectrum.00291-23"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.00291-23","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,13]]},"assertion":[{"value":"2023-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00291-23"}}