{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:27:36Z","timestamp":1788989256177,"version":"build-2803163510"},"reference-count":63,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"ALF","award":["OLL-986652"],"award-info":[{"award-number":["OLL-986652"]}]},{"DOI":"10.13039\/501100023670","name":"Nyckelfonden","doi-asserted-by":"crossref","award":["OLL-595951, OLL-787381"],"award-info":[{"award-number":["OLL-595951, OLL-787381"]}],"id":[{"id":"10.13039\/501100023670","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2024,11,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              <jats:italic>Cutibacterium acnes<\/jats:italic>\n              is a major skin commensal that may act as an opportunistic pathogen. It is difficult to interpret findings of\n              <jats:italic>C. acnes<\/jats:italic>\n              in tissue cultures obtained during arthroplasty revision surgery, since they may represent true infection or contamination. This study investigated whether\n              <jats:italic>C. acnes<\/jats:italic>\n              obtained from prosthetic joint infections (PJIs) were related and shared common genomic traits that might correlate with clinical courses and patient outcomes.\n              <jats:italic>C. acnes<\/jats:italic>\n              isolates from revision surgery of patients with PJIs of the hip, shoulder, and knee were characterized using molecular methods to determine the sequence type (ST) and the presence of possible virulence determinants (Christie\u2013Atkins\u2013Munch-Peterson factors, dermatan sulfate-binding adhesion 1, hyaluronidase lyase, and linear plasmid). A standardized review of the patients\u2019 medical charts was performed. The study included 37 patients with\n              <jats:italic>C. acnes<\/jats:italic>\n              culture-positive tissue samples where multiple isolates of\n              <jats:italic>C. acnes<\/jats:italic>\n              belonged to the same ST. Most of the isolates belonged to phylotype IA\n              <jats:sub>1<\/jats:sub>\n              . Phylogenetic analysis of virulence determinants revealed no shared pattern among PJI isolates. Seven patients had a polymicrobial infection. Exchange revision was performed in 70% of the patients, and &gt;50% of all patients received antibiotic treatment for \u22653 months. Failure was noted in seven patients. No specific ST or any identifiable unique feature among virulence determinants were found among\n              <jats:italic>C. acnes<\/jats:italic>\n              isolated from PJIs of hips and shoulders. The majority of patients had low inflammatory markers and were treated successfully, even polymicrobial infections. However, failure was more common among shoulder infections compared with hip infections.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>IMPORTANCE<\/jats:title>\n            <jats:p>\n              Prosthetic joint infection (PJI) is a rare complication after arthroplasty surgery. The infection seldom resolves without a combination of both surgical and antibiotic treatment and can cause significant suffering among affected patients.\n              <jats:italic>Cutibacterium acnes<\/jats:italic>\n              is a common skin bacterium that is most often found in shoulder PJIs but can also infect other prostheses. In this study, we conducted a review of patients with previously verified PJIs involving\n              <jats:italic>C. acnes<\/jats:italic>\n              in hip or shoulder prostheses, along with a genomic analysis of the bacteria causing the infections. The majority of patients had successful outcomes. We did not identify any specific phylogenetic lineage or specific molecular signature of virulence factors among these PJI-associated\n              <jats:italic>C. acnes<\/jats:italic>\n              isolates that seemed to be associated with increased potential to cause infection among this species. This indicates that\n              <jats:italic>C. acnes<\/jats:italic>\n              isolated from PJIs originates from the patients\u2019 own skin microbiome and is inoculated during the arthroplasty surgery.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/spectrum.00303-24","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T15:44:41Z","timestamp":1728402281000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Genomic characterization and clinical evaluation of prosthetic joint infections caused by\n            <i>Cutibacterium acnes<\/i>"],"prefix":"10.1128","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6355-885X","authenticated-orcid":true,"given":"C.","family":"Liew-Littorin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine and Health, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Davidsson","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine and Health, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5.","family":"Nilsdotter-Augustinsson","sequence":"additional","affiliation":[{"name":"Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Link\u00f6ping University, Link\u00f6ping, \u00d6sterg\u00f6tland, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Hellmark","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7433-0190","authenticated-orcid":true,"given":"H.","family":"Br\u00fcggemann","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5939-2932","authenticated-orcid":false,"given":"B.","family":"S\u00f6derquist","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, \u00d6rebro University, \u00d6rebro, Sweden"},{"name":"School of Medical Sciences, Faculty of Medicine and Health, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_5_3_2","volume-title":"Bone and joint infections: from microbiology to diagnostics and treatment","author":"Werner Z","year":"2015","unstructured":"WernerZ, ed. 2015. 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