{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:37:43Z","timestamp":1787981863129,"version":"build-2784847793"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2022KY869"],"award-info":[{"award-number":["2022KY869"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2025,9,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n              is widely recognized as the chronic infection that is most commonly observed across all age cohorts worldwide and is closely linked to chronic gastritis. In pediatric\n              <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n              patients, we aim to examine the endoscopic and histopathological alterations in the gastric mucosa. This was a potential monocentric investigation conducted from January 2018 to August 2018, collecting 120 children who underwent gastroscopy due to symptoms of gastrointestinal distress. Endoscopic procedures were conducted to acquire mucosal biopsies for the purpose of histopathological analysis. The investigation comprised a cohort of 120 patients, 64 of whom were identified as having\n              <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n              infection.\n              <jats:italic toggle=\"yes\">The H. pylori<\/jats:italic>\n              -infected cohort had a greater level of inflammation, activity, and lymphoid follicles than the\n              <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n              -negative cohort. A significant link was discovered between\n              <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n              infection and both nodular lesions and active gastritis. There was a significant infection link observed between the degree of inflammation and the abundance level of\n              <jats:italic toggle=\"yes\">Helicobacter<\/jats:italic>\n              in the\n              <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n              -infected cohort. There was a significant link between the infection of\n              <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n              and histopathological manifestations, including active gastritis.\n            <\/jats:p>\n            <jats:sec>\n              <jats:title>IMPORTANCE<\/jats:title>\n              <jats:p>\n                <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                is a significant concern of infection in the field of public health. In children, the endoscopic observations of\n                <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                infection exhibit variation, particularly in highly endemic countries where nodular changes in the gastric mucosa are commonly observed. Nevertheless, there is ongoing debate regarding the connection between the colonization level of\n                <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                in the gastric mucosa and the extent of histological parameters of gastritis. We mainly explored the link between the\n                <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                colonization density in the gastric mucosa and the severity of histological parameters related to gastritis and found that there was a significant link between the infection of\n                <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                and histopathological manifestations, including active gastritis.\n              <\/jats:p>\n            <\/jats:sec>\n          <\/jats:sec>","DOI":"10.1128\/spectrum.00312-25","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T13:00:48Z","timestamp":1753794048000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Correlation between\n            <i>Helicobacter pylori<\/i>\n            infection and severity of gastritis in children"],"prefix":"10.1128","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2759-9247","authenticated-orcid":true,"given":"Wei","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaofeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerong","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fubang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4829-2041","authenticated-orcid":false,"given":"Mizu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Children's Hospital, Zhejiang 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