{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:05:59Z","timestamp":1791450359446,"version":"4.3.3"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T00:00:00Z","timestamp":1635638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T00:00:00Z","timestamp":1635638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100004587","name":"MEC | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CP15\/00132"],"award-info":[{"award-number":["CP15\/00132"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"MEC | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/01378"],"award-info":[{"award-number":["PI16\/01378"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"MEC | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/01453"],"award-info":[{"award-number":["PI19\/01453"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"MEC | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD16\/0016\/0009"],"award-info":[{"award-number":["RD16\/0016\/0009"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2021,10,31]]},"abstract":"<jats:p>\n                    The development of new antimicrobial therapeutic strategies requires immediate attention to avoid the tens of millions of deaths predicted to occur by 2050 as a result of MDR bacterial infections. In this study, we assessed the antibacterial activity of three major tamoxifen metabolites,\n                    <jats:italic>N<\/jats:italic>\n                    -desmethyltamoxifen (DTAM), 4-hydroxytamoxifen (HTAM), and endoxifen (ENDX), against methicillin-resistant\n                    <jats:named-content content-type=\"genus-species\">Staphylococcus epidermidis<\/jats:named-content>\n                    (MRSE) and\n                    <jats:italic>Enterococcus<\/jats:italic>\n                    spp. (\n                    <jats:named-content content-type=\"genus-species\">E. faecalis<\/jats:named-content>\n                    and\n                    <jats:named-content content-type=\"genus-species\">E. faecium<\/jats:named-content>\n                    ).\n                  <\/jats:p>","DOI":"10.1128\/spectrum.00403-21","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T10:00:42Z","timestamp":1634810442000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Repurposing of the Tamoxifen Metabolites to Treat Methicillin-Resistant Staphylococcus epidermidis and Vancomycin-Resistant Enterococcus faecalis Infections"],"prefix":"10.1128","volume":"9","author":[{"given":"Andrea","family":"Mir\u00f3-Canturri","sequence":"first","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Virgen del Roc\u00edo University Hospital, Seville, Spain"},{"name":"Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Vila-Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Virgen del Roc\u00edo University Hospital, Seville, Spain"},{"name":"Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Caretero-Ledesma","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Virgen del Roc\u00edo University Hospital, Seville, Spain"},{"name":"Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Ayerbe-Algaba","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Virgen del Roc\u00edo University Hospital, Seville, Spain"},{"name":"Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jer\u00f3nimo","family":"Pach\u00f3n","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"},{"name":"Department of Medicine, University of Seville, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Enrique","family":"Jim\u00e9nez-Mej\u00edas","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Virgen del Roc\u00edo University Hospital, Seville, Spain"},{"name":"Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"},{"name":"Department of Medicine, University of Seville, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9302-8384","authenticated-orcid":true,"given":"Younes","family":"Smani","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Virgen del Roc\u00edo University Hospital, Seville, Spain"},{"name":"Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00109-13"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.11.012"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.254"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2565(03)71333-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2017.0022"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-018-3295-6"},{"key":"e_1_3_3_8_2","volume-title":"StatPearls.","author":"Levitus M","year":"2020","unstructured":"Levitus M, Rewane A, Perera TB. 2020. Vancomycin-resistant enterococci (VRE). In StatPearls. StatPearls Publishing, Treasure Island (FL)."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph14060507"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.201900439"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9369"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3283656bc1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02272-18"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-019-3012-7"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00765-13"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100829"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10030336"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3480"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep16407"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124595"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00750"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03869-14"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq257"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01564-08"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125927"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb500828m"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200342040-00004"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05606-11"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9010036"},{"key":"e_1_3_3_30_2","volume-title":"Performance standards for antimicrobial susceptibility testing, 29th ed.","author":"Clinical and Laboratory Standards Institute.","year":"2019","unstructured":"Clinical and Laboratory Standards Institute. 2019. Performance standards for antimicrobial susceptibility testing, 29th ed. CLSI, Wayne, PA, USA."},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa103"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.1998.tb00061.x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.634323"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/Spectrum.00403-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/Spectrum.00403-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T03:46:26Z","timestamp":1646711186000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/Spectrum.00403-21"}},"subtitle":[],"editor":[{"given":"Kunyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,10,31]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,10,31]]}},"alternative-id":["10.1128\/Spectrum.00403-21"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.00403-21","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.05.20.445078","asserted-by":"object"}]},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,31]]},"assertion":[{"value":"2021-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00403-21"}}