{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:30:14Z","timestamp":1788971414458,"version":"build-2803163510"},"reference-count":31,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              In recent years, the incidence and drug resistance of\n              <jats:italic>Candida parapsilosis<\/jats:italic>\n              have increased. Our study aimed to determine the antifungal sensitivity of\n              <jats:italic>C. parapsilosis<\/jats:italic>\n              and the clinical and demographic characteristics of children with candidemia. Two hundred pediatric patients with\n              <jats:italic>C. parapsilosis<\/jats:italic>\n              candidemia were included in the study between 1 January 2010 and 1 August 2023. Clinical samples were evaluated on a BACTEC-FX-40 automatic blood culture device (Becton Dickinson, USA). Yeast isolates were identified to the species level via identification cards (YST) using the VITEK 2 Compact (bioMeri\u00e9ux, France) system. Antifungal susceptibility was performed using antifungal cell cards (AST-YST01). Approval for the study was received from the \u201cUniversity Faculty of Medicine\u201d Hospital Clinical Research Ethics Committee. Non-catheter candidemia was detected in 127 (63.5%) patients, and catheter-related candidemia was detected in 73 (36.5%) patients. It was observed that the patients\u2019 history of malignancy, mechanical ventilation, urinary catheter, nasogastric tube, and intensive care unit stay was associated with\n              <jats:italic>C. parapsilosis<\/jats:italic>\n              mortality. The mortality rate from candidemia was 9.5%. The most frequently preferred antifungal agents were amphotericin B and fluconazole. The fluconazole drug resistance rate was found to be 6%, and the amphotericin B drug resistance rate was 4%. Because\n              <jats:italic>C. parapsilosis<\/jats:italic>\n              candidemia mortality rates can be high depending on risk factors and clinical characteristics, it is important to initiate appropriate and timely antifungal therapy. We think that our study can provide important information about the clinical profiles, distributions, susceptibility profiles, and control of antifungal resistance of\n              <jats:italic>C. parapsilosis<\/jats:italic>\n              isolates.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>IMPORTANCE<\/jats:title>\n            <jats:p>\n              It has been observed that the frequency and antifungal resistance of\n              <jats:italic>Candida parapsilosis<\/jats:italic>\n              have increased recently. In our study, we aimed to determine the antifungal sensitivity of\n              <jats:italic>C. parapsilosis<\/jats:italic>\n              and the clinical and demographic characteristics of children with candidemia. It was observed that the patients\u2019 history of malignancy, mechanical ventilation, urinary catheter, nasogastric tube, and intensive care stay was associated with\n              <jats:italic>C. parapsilosis<\/jats:italic>\n              mortality. The mortality rate from candidemia was 9.5%. The most frequently preferred antifungal agents were amphotericin B and fluconazole. The fluconazole drug resistance rate was found to be 6%, and the amphotericin B drug resistance rate was 4%. Because\n              <jats:italic>C. parapsilosis<\/jats:italic>\n              candidemia mortality rates can be high depending on risk factors and clinical characteristics, it is important to initiate appropriate and timely antifungal therapy.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/spectrum.00564-24","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T13:07:30Z","timestamp":1718197650000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["<i>Candida parapsilosis<\/i>\n            candidemia in children admitted to a tertiary hospital in Turkey: clinical features and antifungal susceptibility"],"prefix":"10.1128","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0471-8939","authenticated-orcid":true,"given":"Fatma Tu\u011fba","family":"\u00c7etin","sequence":"first","affiliation":[{"name":"Department of Pediatric Infection, Faculty of Medicine, Cukurova University, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dcmm\u00fchan","family":"\u00c7ay","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infection, Faculty of Medicine, Cukurova University, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Child Health and Diseases, Faculty of Medicine, Cukurova University, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"K\u0131l\u0131n\u00e7","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infection, Faculty of Medicine, Cukurova University, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asena","family":"\u00dcnal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infection, Faculty of Medicine, Cukurova University, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisa Nur","family":"Tapa\u00e7","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infection, Faculty of Medicine, Cukurova University, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem \u00d6zg\u00fcr","family":"G\u00fcnde\u015flio\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infection, Faculty of Medicine, Cukurova University, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"Alabaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infection, Faculty of Medicine, Cukurova University, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevcan","family":"Bilen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency Medicine, Cukurova University, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filiz","family":"Kibar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Cukurova University, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazl\u0131","family":"Totik","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Medicine, Cukurova University, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4328\/JCAM.6090"},{"key":"e_1_3_3_3_2","first-page":"397","article-title":"Update on management of invasive candidiasis","volume":"30","author":"Candel FJ","year":"2017","unstructured":"Candel FJ, Pazos Pacheco C, Ruiz-Camps I, Maseda E, S\u00e1nchez-Benito MR, Montero A, Puig M, Gilsanz F, Aguilar J, Matesanz M. 2017. 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