{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:44:26Z","timestamp":1790833466571,"version":"4.1.0"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2021,9,3]]},"abstract":"<jats:p>Similar findings have not yet been reported in Brazil, emphasizing the importance of monitoring small-colony variants (SCVs). Altogether, our results highlight the need to improve detection methods and review antimicrobial therapy protocols in cystic fibrosis (CF) patients.<\/jats:p>","DOI":"10.1128\/spectrum.00614-21","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T14:30:58Z","timestamp":1627482658000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Emergence of Thymidine-Dependent Staphylococcus aureus Small-Colony Variants in Cystic Fibrosis Patients in Southern Brazil"],"prefix":"10.1128","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3095-5273","authenticated-orcid":false,"given":"Dilair Camargo","family":"de Souza","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Bacteriologia, Complexo Hospital de Cl\u00ednicas, Universidade Federal do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Lucia","family":"Cogo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bacteriologia, Complexo Hospital de Cl\u00ednicas, Universidade Federal do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libera Maria","family":"Dalla-Costa","sequence":"additional","affiliation":[{"name":"Faculdades e Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula de Oliveira","family":"Tomaz","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bacteriologia, Complexo Hospital de Cl\u00ednicas, Universidade Federal do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"},{"name":"Faculdades e Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0637-4957","authenticated-orcid":false,"given":"Daniele","family":"Conte","sequence":"additional","affiliation":[{"name":"Faculdades e Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Antonio","family":"Riedi","sequence":"additional","affiliation":[{"name":"Departamento de Pediatria, Complexo Hospital de Cl\u00ednicas, Universidade Federal do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson Augusto","family":"Rosario Filho","sequence":"additional","affiliation":[{"name":"Departamento de Pediatria, Complexo Hospital de Cl\u00ednicas, Universidade Federal do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussara Kasuko","family":"Palmeiro","sequence":"additional","affiliation":[{"name":"Faculdades e Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Curitiba, Paran\u00e1, Brazil"},{"name":"Departamento de An\u00e1lises Cl\u00ednicas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal de Santa Catarina, Florian\u00f3polis, Santa Catarina, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01510-06"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2013.05.016"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00069-15"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16111940"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00321"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099390"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00742-15"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24730"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02330-15"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00099"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1384"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm037"},{"key":"e_1_3_2_14_2","first-page":"683","article-title":"Identification of clinical thymidine-dependent small-colony variants of Staphylococcus aureus by using matrix-assisted laser desorption ionization time-of-flight mass spectrometry","volume":"63","author":"Ota Y","year":"2015","unstructured":"Ota Y, Matsumoto T, Sugano M, Honda T. 2015. Identification of clinical thymidine-dependent small-colony variants of Staphylococcus aureus by using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Rinsho Byori 63:683\u2013687.","journal-title":"Rinsho Byori"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03570.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2007.02.003"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-016-0994-z"},{"key":"e_1_3_2_18_2","first-page":"475","article-title":"Prevalence, antibiotic and pulsed-field gel electrophoresis patterns of Staphylococcus aureus small-colony variants in cystic fibrosis patients","volume":"47","author":"Pakasticali N","year":"2016","unstructured":"Pakasticali N, Kaya G, Senel U, Kipritci O, Tamay Z, Guler N, Nazik H, Ongen B. 2016. Prevalence, antibiotic and pulsed-field gel electrophoresis patterns of Staphylococcus aureus small-colony variants in cystic fibrosis patients. Southeast Asian J Trop Med Public Health 47:475\u2013484.","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10050971"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl014"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.37148"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.1.211-215.2002"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068462"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03742.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.791"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3402\/dfa.v6.26431"},{"key":"e_1_3_2_27_2","first-page":"235","article-title":"Characterization of Staphylococcus aureus small colony variant strains isolated from Italian patients attending a regional cystic fibrosis care centre","volume":"38","author":"Morelli P","year":"2015","unstructured":"Morelli P, De Alessandri A, Manno G, Marchese A, Bandettini R, Bassi M, Lobello R, Minicucci L. 2015. Characterization of Staphylococcus aureus small colony variant strains isolated from Italian patients attending a regional cystic fibrosis care centre. New Microbiol 38:235\u2013243.","journal-title":"New Microbiol"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit270"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00835-11"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00912-07"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1904861116"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2018.04.008"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040458"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02219"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01170-11"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.14826.1"},{"key":"e_1_3_2_37_2","volume-title":"Screening of MRSA: a comparison between one and multiple sites sample collection using the new ESWAB MRSA collection kit. Abstr C-049.","author":"Silbert S","year":"2009","unstructured":"Silbert S, Menezes LC, Monteiro J, Gabriela M, Ribeiro C, Pereira SC, Pignatari ACC, Kit EM. 2009. Screening of MRSA: a comparison between one and multiple sites sample collection using the new ESWAB MRSA collection kit. Abstr C-049. ASM, 109th General Meeting, Philadelphia, PA."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.7.2155-2161.2002"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00351-10"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2012.12.008"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02799-06"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/Spectrum.00614-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/Spectrum.00614-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T08:42:57Z","timestamp":1646728977000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/Spectrum.00614-21"}},"subtitle":[],"editor":[{"given":"Joanna B.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,9,3]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,9,3]]}},"alternative-id":["10.1128\/Spectrum.00614-21"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.00614-21","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,3]]},"assertion":[{"value":"2021-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00614-21"}}