{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:13:52Z","timestamp":1790860432909,"version":"4.1.0"},"reference-count":86,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","award":["3220-29047"],"award-info":[{"award-number":["3220-29047"]}],"id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U01AI123394"],"award-info":[{"award-number":["U01AI123394"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI155893"],"award-info":[{"award-number":["R01AI155893"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["F30AI157161"],"award-info":[{"award-number":["F30AI157161"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2022,6,29]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Pseudomonas aeruginosa<\/jats:named-content>\n            is associated with serious infections, and treatment can be challenging. Because of this, carbapenems and \u03b2-lactam\/\u03b2-lactamase inhibitor combinations have become critical tools in treating multidrug-resistant (MDR)\n            <jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>\n            infections, but increasing resistance threatens their efficacy.\n          <\/jats:p>","DOI":"10.1128\/spectrum.00766-22","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T13:02:24Z","timestamp":1654002144000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Genomic Surveillance of Clinical Pseudomonas aeruginosa Isolates Reveals an Additive Effect of Carbapenemase Production on Carbapenem Resistance"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6586-2811","authenticated-orcid":true,"given":"Luke","family":"Diorio-Toth","sequence":"first","affiliation":[{"name":"The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidra","family":"Irum","sequence":"additional","affiliation":[{"name":"Atta ur Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Potter","sequence":"additional","affiliation":[{"name":"The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan A.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Arslan","sequence":"additional","affiliation":[{"name":"Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tehmina","family":"Munir","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadia","family":"Andleeb","sequence":"additional","affiliation":[{"name":"Atta ur Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1137-840X","authenticated-orcid":true,"given":"Carey-Ann D.","family":"Burnham","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0455-8370","authenticated-orcid":true,"given":"Gautam","family":"Dantas","sequence":"additional","affiliation":[{"name":"The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","article-title":"WHO publishes list of bacteria for which new antibiotics are urgently needed","author":"WHO","year":"2017","unstructured":"WHO. 2017. WHO publishes list of bacteria for which new antibiotics are urgently needed. World Health Organization.","journal-title":"World Health Organization"},{"key":"e_1_3_3_3_2","volume-title":"Antibiotic Resistance Threats in the United States, 2019.","author":"CDC","year":"2019","unstructured":"CDC. 2019. Antibiotic Resistance Threats in the United States, 2019. U.S. Department of Health and Human Services C, Atlanta, GA."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2507.181200"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00756-06"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2106.141504"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12563-1"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000730"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2018.11.013"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.7665"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70059-7"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.02.018"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00572"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.614058"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2015.02.024"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.3.880-886.2006"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn512"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10111386"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34020-7"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evz119"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9090600"},{"key":"e_1_3_3_22_2","unstructured":"Seemann T. mlst on Github. https:\/\/github.com\/tseemann\/mlst. Accessed April 21 2021."},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.14826.1"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00825-15"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2020.05.001"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.01026-20"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-0966-5"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00040-09"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03570.x"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70143-2"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-021-00870-7"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki008"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.9.5329-5334.2001"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1997.4891851.x"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.11.2385"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.04.004"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05451-11"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2013.10.027"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf436"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu033"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.12.3322-3327.2000"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.5.1633-1641.2006"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.8.2696-2699.2002"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.5.1410-1414.2000"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04210.x"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.5.1782-1786.2005"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.2.480-484.2001"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.5.1797-1802.2004"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.2.287"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.305.5400"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2019.08.019"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2019.0387"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02122-20"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00535-17"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.052555-0"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.010017-0"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evy259"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02874-20"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa122"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01375-19"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01025-07"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3117"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01272"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000132"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1227"},{"key":"e_1_3_3_66_2","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing.","author":"CLSI","year":"2020","unstructured":"CLSI. 2020. Performance Standards for Antimicrobial Susceptibility Testing. Clinical & Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128036"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt086"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.186072.114"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu153"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv421"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409137102"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/35023079"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2006-7-10-r90"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.086082.108"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2016.10.002"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1128\/MRA.00865-19"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2012.02795.x"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009490"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab301"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-91456-0"},{"key":"e_1_3_3_83_2","unstructured":"Seemann T. Snippy on Github. https:\/\/github.com\/tseemann\/snippy. Accessed April 22 2021."},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq033"},{"key":"e_1_3_3_85_2","unstructured":"Team RC. 2021. R: a language and environment for statistical computing. R Foundation for Statistical Computing Vienna Austria. https:\/\/www.R-project.org\/."},{"key":"e_1_3_3_86_2","unstructured":"Oksanen Jari Blanchet FGM Friendly R Kindt P Legendre D McGlinn PR Minchin RB O'Hara GL Simpson P Solymos MHS Eduard S Helene W. 2020. vegan: Community Ecology Package. R package version 2.5\u20137 https:\/\/CRAN.R-project.org\/package=vegan."},{"key":"e_1_3_3_87_2","unstructured":"Ogle DH Doll JC Wheeler P Dinno A. 2022. FSA: fisheries Stock Analysis. R package version 0.9.3."}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.00766-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.00766-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T13:47:16Z","timestamp":1656510436000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.00766-22"}},"subtitle":[],"editor":[{"given":"Daria Van","family":"Tyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,6,29]]},"references-count":86,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6,29]]}},"alternative-id":["10.1128\/spectrum.00766-22"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.00766-22","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,29]]},"assertion":[{"value":"2022-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00766-22"}}