{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T23:35:09Z","timestamp":1775086509651,"version":"3.50.1"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2021R1I1A1A01052391"],"award-info":[{"award-number":["2021R1I1A1A01052391"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"crossref","award":["HV23C0090"],"award-info":[{"award-number":["HV23C0090"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2024,8,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n \n \n Mycobacterium kansasii<\/jats:italic>\n is a bacterium included in non-tuberculous mycobacteria (NTM) that can cause lung disease. It shares a significant number of antigens with\n Mycobacterium tuberculosis<\/jats:italic>\n (Mtb), suggesting that it has the potential to be used as a tuberculosis (TB) vaccine. Therefore, we subcutaneously vaccinated mice with reference strain,\n M. kansasii<\/jats:italic>\n -ATCC12478 [\n M. kansasii<\/jats:italic>\n -American Type Culture Collection (ATCC)], and clinically isolated strain,\n M. kansasii<\/jats:italic>\n -SM-1 to evaluate potential as a TB vaccine by comparing with bacille Calmette-Guerin (BCG) vaccine. Ten weeks after vaccination, we evaluated immunogenicity of\n M. kansasii<\/jats:italic>\n -ATCC and\n M. kansasii<\/jats:italic>\n -SM-1, and\n M. kansasii<\/jats:italic>\n -SM-1 immunization induces potent Mtb antigen-specific IFN-\u03b3-producing CD4\n +<\/jats:sup>\n T cells than\n M. kansasii<\/jats:italic>\n -ATCC. Upon Mtb infection,\n M. kansasii<\/jats:italic>\n -SM-1 provided better protection than\n M. kansasii<\/jats:italic>\n -ATCC, which was comparable to the efficacy of BCG. These results showed that the clinical strain\n M. kansasii<\/jats:italic>\n -SM-1, which exhibits an enhanced Mtb antigen-specific Th1 response, shows greater vaccine efficacy compared to\n M. kansasii<\/jats:italic>\n -ATCC. In this study, we demonstrated that vaccine efficacy can vary depending on the strain of\n M. kansasii<\/jats:italic>\n and that its efficacy can be comparable to BCG. This suggests that\n M. kansasii<\/jats:italic>\n has the potential to be a live TB vaccine candidate.\n <\/jats:p>\n \n IMPORTANCE<\/jats:title>\n \n Mycobacterium kansasii<\/jats:italic>\n , a non-tuberculous mycobacteria (NTM) species causing lung disease, shares key antigens with\n Mycobacterium tuberculosis<\/jats:italic>\n (Mtb), indicating its potential for TB vaccine development. Subcutaneous vaccination of mice with\n M. kansasii<\/jats:italic>\n strains reference strain\n M. kansasii<\/jats:italic>\n -ATCC12478 [(\n M. kansasii<\/jats:italic>\n -American Type Culture Collection (ATCC)] and clinically isolated strain\n M. kansasii<\/jats:italic>\n -SM-1 revealed differences in immunogenicity.\n M. kansasii<\/jats:italic>\n -SM-1 induced a robust Mtb antigen-specific IFN-\u03b3-producing CD4\n +<\/jats:sup>\n T cell response compared to\n M. kansasii<\/jats:italic>\n -ATCC. Additionally,\n M. kansasii<\/jats:italic>\n -SM-1 conferred better protection against Mtb infection than\n M. kansasii<\/jats:italic>\n -ATCC, which is comparable to bacille Calmette-Guerin (BCG). These findings underscore the variable vaccine efficacy among\n M. kansasii<\/jats:italic>\n strains, with\n M. kansasii<\/jats:italic>\n -SM-1 exhibiting promising potential as a live TB vaccine candidate, suggesting its comparative effectiveness to BCG.\n <\/jats:p>\n <\/jats:sec>\n <\/jats:sec>","DOI":"10.1128\/spectrum.00819-24","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T13:02:05Z","timestamp":1720530125000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Immunogenicity and vaccine potential of clinical isolate\n Mycobacterium kansasii<\/i>\n strain against\n Mycobacterium tuberculosis<\/i>\n infection"],"prefix":"10.1128","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9215-2831","authenticated-orcid":false,"given":"Hongmin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Microbiology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0854-4582","authenticated-orcid":false,"given":"Sung Jae","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-20017-w"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.02.057"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1193058"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2014.10.002"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1211"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.2.672-678.2002"},{"key":"e_1_3_5_8_2","first-page":"543","article-title":"\"Immunization mobile\" brings protection to children in southeastern Idaho","volume":"102","author":"Stanger L","year":"1987","unstructured":"Stanger L. 1987. \"Immunization mobile\" brings protection to children in southeastern Idaho. 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Infection with Mycobacterium kansasii and efficacy of vaccination against tuberculosis. 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