{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:42:03Z","timestamp":1789472523401,"version":"build-2803163510"},"reference-count":64,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"The cultivation project of Zhuhai People's Hospital"},{"name":"The Medical and Health Project of Zhuhai Science and Technology Plan"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2023,10,17]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acute pancreatitis (AP) is a type of digestive system disease with high mortality. Previous studies have shown that gut microbiota can participate in developing and treating acute pancreatitis by affecting the host\u2019s metabolism. In this study, we followed 20 AP patients to generate longitudinal gut microbiota profiles and activity during disease (before treatment, on the third day of treatment, and 1 month after discharge). We analyzed species composition and metabolic pathways\u2019 changes across the treatment phase, severity, and etiology. The diversity of the gut microbiome of patients with AP did not show much variation with treatment. In contrast, the metabolic functions of the gut microbiota, such as the essential chemical reactions that produce energy and maintain life, were partially reinstated after treatment. The severe AP (SAP) patients contained less beneficial bacteria (i.e.,\n                    <jats:italic toggle=\"yes\">Bacteroides xylanisolvens<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Clostridium lavalense,<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Roseburia inulinivorans<\/jats:italic>\n                    ) and weaker sugar degradation function than mild AP patients before treatment. Moreover, etiology was one of the drivers of gut microbiome composition and explained the 3.54% variation in species\u2019 relative abundance. The relative abundance of pathways related to lipid synthesis was higher in the gut of hyperlipidemia AP patients than in biliary AP patients. The composition and functional profiles of the gut microbiota reflect the severity and etiology of AP. Otherwise, we also identified bacterial species associated with SAP, i.e.,\n                    <jats:italic toggle=\"yes\">Oscillibacter<\/jats:italic>\n                    sp\n                    <jats:italic toggle=\"yes\">.<\/jats:italic>\n                    57_20\n                    <jats:italic toggle=\"yes\">, Parabacteroides johnsonii, Bacteroides stercoris, Methanobrevibacter smithii, Ruminococcus lactaris, Coprococcus comes,<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Dorea formicigenerans<\/jats:italic>\n                    , which have the potential to identify the SAP at an early stage.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Acute pancreatitis (AP) is a type of digestive system disease with high mortality. Previous studies have shown that gut microbiota can participate in the development and treatment of acute pancreatitis by affecting the host\u2019s metabolism. However, fewer studies acquired metagenomic sequencing data to associate species to functions intuitively and performed longitudinal analysis to explore how gut microbiota influences the development of AP. We followed 20 AP patients to generate longitudinal gut microbiota profiles and activity during disease and studied the differences in intestinal flora under different severities and etiologies. We have two findings. First, the gut microbiota profile has the potential to identify the severity and etiology of AP at an early stage. Second, gut microbiota likely acts synergistically in the development of AP. This study provides a reference for characterizing the driver flora of severe AP to identify the severity of acute pancreatitis at an early stage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.00829-23","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T09:01:21Z","timestamp":1694509281000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["Composition and functional profiles of gut microbiota reflect the treatment stage, severity, and etiology of acute pancreatitis"],"prefix":"10.1128","volume":"11","author":[{"given":"Zhenjiang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Zhuhai Hospital Affiliated with Jinan University (Zhuhai People\u2019s Hospital)","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhuhai Hospital Affiliated with Jinan University (Zhuhai People\u2019s Hospital)","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Management, University of Science and Technology of China","place":["Hefei, China"]},{"name":"Department of Research and Development, Shenzhen Byoryn Technology Co., Ltd.","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuangming","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Gaolangang Branch of Zhuhai People\u2019s Hospital (Hospital of Gaolangang)","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhuhai Hospital Affiliated with Jinan University (Zhuhai People\u2019s Hospital)","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhuo","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhuhai Hospital Affiliated with Jinan University (Zhuhai People\u2019s Hospital)","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhe","family":"Li","sequence":"additional","affiliation":[{"name":"College of Medicine and Biological Information Engineering, Northeastern University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbo","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhuhai Hospital Affiliated with Jinan University (Zhuhai People\u2019s Hospital)","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhuhai Hospital Affiliated with Jinan University (Zhuhai People\u2019s Hospital)","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Medicine and Biological Information Engineering, Northeastern University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxiang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8057-8559","authenticated-orcid":false,"given":"Yuping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhuhai Hospital Affiliated with Jinan University (Zhuhai People\u2019s Hospital)","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.JAA.0000830176.03626.15"},{"key":"e_1_3_5_3_2","first-page":"407","article-title":"Severe acute pancreatitis: surgical management in a third-level hospital","volume":"77","author":"Serv\u00edn-Torres E","year":"2009","unstructured":"Serv\u00edn-Torres E , Vel\u00e1zquez-Garc\u00eda JA , Delgadillo-Teyer G , Galindo-Mendoza L , Bevia-P\u00e9rez F , Rivera-Bennet F . 2009. 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