{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:51:50Z","timestamp":1786117910958,"version":"build-2736575974"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"The Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2023ZD0506200"],"award-info":[{"award-number":["2023ZD0506200"]}]},{"name":"The Jiangxi Province Graduate Innovation Special Fund Project","award":["YC2025-B197"],"award-info":[{"award-number":["YC2025-B197"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      This study aims to examine the differences in microbial community abundance and species distribution in the bronchoalveolar lavage fluid (BALF) obtained from non-cystic fibrosis bronchiectasis (NCFB) patients between those with and without\n                      <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      ) colonization, and to assess the impact of\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      colonization on airway microecological imbalance in NCFB. Sixty-four patients were enrolled, grouped into\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      -colonized (PA, 29) and non-colonized (NPA, 35) groups. Among patients with NCFB, those with\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      colonization had greater disease severity than those without colonization, with significantly higher bronchiectasis severity index (BSI) scores (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). The proportions of patients with higher Bhalla and E-FACED scores were also greater in the PA group than in the NPA group (62.1% vs 42.8% and 34.1% vs 20%, respectively). Annual hospitalization frequency was numerically higher in PA (2.14 \u00b1 2.43 vs 1.47 \u00b1 0.86;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.543). The PA group exhibited poorer pulmonary function, with significantly lower FEV1 and FEV1% predicted (both\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). In addition, NCFB patients in the PA group showed higher proportions of elevated white blood cell counts (31% vs 17.1%) and neutrophil percentages (41.4% vs 31.4%). Microbiota analysis of BALF demonstrated reduced alpha diversity in NCFB patients with\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      colonization, with a predominance of\n                      <jats:italic toggle=\"yes\">Pseudomonas<\/jats:italic>\n                      , whereas non-colonized NCFB patients had relatively higher abundances of\n                      <jats:italic toggle=\"yes\">Streptococcus<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Acinetobacter<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Rothia<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Veillonella<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">Prevotella<\/jats:italic>\n                      . Overall,\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      colonization in NCFB is associated with increased disease severity, heightened inflammation, and impaired lung function, accompanied by decreased microbial diversity,\n                      <jats:italic toggle=\"yes\">Pseudomonas<\/jats:italic>\n                      dominance, and suppression of commensal taxa.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>IMPORTANCE<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                      is a common colonizer in the airways of patients with non-cystic fibrosis bronchiectasis (NCFB), linked to disease severity, but research on its impact on clinical outcomes and airway microbiome diversity remains limited. This study compared\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      -colonized (PA group) and non-colonized (NPA group) NCFB patients and found that the PA group had more severe disease (higher exacerbation, severity scores) and reduced bronchoalveolar lavage fluid (BALF) microbial \u03b1\/\u03b2 diversity (marked by\n                      <jats:italic toggle=\"yes\">Pseudomonas<\/jats:italic>\n                      dominance and suppressed symbionts like\n                      <jats:italic toggle=\"yes\">Streptococcus<\/jats:italic>\n                      ). These findings indicate that\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      reshapes the microecology and is associated with airway microbial imbalance. This study confirms that\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      colonization is a key factor in NCFB disease progression and airway microecological imbalance, highlighting reduced colonization and restored homeostasis as precision intervention strategies that inform targeted therapies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.00871-26","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T13:04:36Z","timestamp":1782219876000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of clinical characteristics and bronchoalveolar lavage fluid microbial community diversity in non-cystic fibrosis bronchiectasis patients with\n                    <i>Pseudomonas aeruginosa<\/i>\n                    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