{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T21:57:45Z","timestamp":1775253465543,"version":"3.50.1"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100016956","name":"Melinta Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2022,10,26]]},"abstract":"<jats:p>\n            Resistance-nodulation-cell division (RND) efflux pumps play a major role in intrinsic and acquired antibiotic resistance in\n            <jats:named-content content-type=\"genus-species\">Burkholderia pseudomallei<\/jats:named-content>\n            , and these pumps are its only known multidrug resistance determinants. Fluoroquinolones have performed poorly in clinical settings and are currently not recommended for treatment of\n            <jats:named-content content-type=\"genus-species\">B. pseudomallei<\/jats:named-content>\n            infections.\n          <\/jats:p>","DOI":"10.1128\/spectrum.00903-22","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T13:00:51Z","timestamp":1660654851000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Delafloxacin against a Burkholderia pseudomallei Efflux Mutant Panel"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1702-9072","authenticated-orcid":true,"given":"Sandra P.","family":"McCurdy","sequence":"first","affiliation":[{"name":"Melinta Therapeutics, Morristown, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawarat","family":"Somprasong","sequence":"additional","affiliation":[{"name":"The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8847-335X","authenticated-orcid":true,"given":"Herbert P.","family":"Schweizer","sequence":"additional","affiliation":[{"name":"The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00006-19"},{"key":"e_1_3_1_3_2","unstructured":"CDC. 2021. Melioidosis. https:\/\/www.cdc.gov\/melioidosis\/index.html."},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.107"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7915.2012.00334.x"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01172-17"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00956-19"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00305"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00268-17"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01803-09"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy069"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01357-17"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000691"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2018-0155"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw529"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12613"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00736-21"},{"key":"e_1_3_1_18_2","volume-title":"Methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria","author":"Clinical and Laboratory Standards Institute","year":"2016","unstructured":"Clinical and Laboratory Standards Institute. 2016. Methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria, 3rd ed. CLSI Document M45. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"3"},{"key":"e_1_3_1_19_2","volume-title":"Performance standards for antimicrobial susceptibility testing.","author":"Clinical and Laboratory Standards Institute","year":"2021","unstructured":"Clinical and Laboratory Standards Institute. 2021. Performance standards for antimicrobial susceptibility testing. CLSI Document M100-S31. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036507"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.01.094"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.00903-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.00903-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T14:07:39Z","timestamp":1666793259000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.00903-22"}},"subtitle":[],"editor":[{"given":"Neha","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10,26]]}},"alternative-id":["10.1128\/spectrum.00903-22"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.00903-22","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,26]]},"assertion":[{"value":"2022-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00903-22"}}