{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:00:20Z","timestamp":1789668020758,"version":"4.0.1"},"reference-count":45,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"MOST | National Key Research and Development Program of China","award":["2023YFC3603104"],"award-info":[{"award-number":["2023YFC3603104"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2025,1,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              <jats:italic>Proteus mirabilis<\/jats:italic>\n              , a significant pathogenic bacterium within the Enterobacteriaceae family, is widely distributed across various natural environments. This study conducted a genomic comparison analysis of 1,267 strains of\n              <jats:italic>P. mirabilis<\/jats:italic>\n              using extensive genome data from public databases. The objective was to elucidate the pan-genomic structure of\n              <jats:italic>P. mirabilis<\/jats:italic>\n              , revealing the composition and distribution of core and accessory gene families among different strains. Additionally, an attempt was made to construct a core genome multilocus sequence typing scheme specific to this species in order to enhance the precision of describing genetic diversity and evolutionary relationships. Furthermore, the study delved into the mechanisms of resistance of\n              <jats:italic>P. mirabilis<\/jats:italic>\n              to carbapenems and quinolones. Our findings underscore significant challenges posed by\n              <jats:italic>P. mirabilis<\/jats:italic>\n              in terms of antibiotic resistance, with widespread resistance observed particularly against beta-lactams and an increasing trend in resistance to carbapenems and quinolones. These results highlight the severity of\n              <jats:italic>P. mirabilis<\/jats:italic>\n              as a pathogen and underscore its rapid evolution and adaptability in developing resistance. This study aims to deepen our understanding of the antibiotic resistance of\n              <jats:italic>P. mirabilis<\/jats:italic>\n              , providing important insights for the development of future antimicrobial drugs, promoting effective treatment and control of this pathogen, and mitigating its threat to human health.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>IMPORTANCE<\/jats:title>\n            <jats:p>\n              The bacterium\n              <jats:italic>Proteus mirabilis<\/jats:italic>\n              is a common pathogenic bacterium that is known to cause a variety of human infections. The drug-resistant genes carried by\n              <jats:italic>P. mirabilis<\/jats:italic>\n              present a significant challenge to clinical treatment, particularly in regard to the organism\u2019s notable resistance to commonly used beta-lactam and quinolone drugs. Furthermore, the prevalence of the urease gene cluster of\n              <jats:italic>P. mirabilis<\/jats:italic>\n              at the urease gene level may be associated with the formation of kidney stones. The objective of the study is to analyze the bacterium\u2019s drug resistance, urease gene clusters, and gene distribution in genomes in order to facilitate the development of antimicrobial drugs and improve the treatment and control of\n              <jats:italic>P. mirabilis<\/jats:italic>\n              infections.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/spectrum.00992-24","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T14:02:21Z","timestamp":1733493741000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Genomic insights on cgMLST markers, drug resistance, and urease cluster of\n            <i>Proteus mirabilis<\/i>\n            strains"],"prefix":"10.1128","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5997-1253","authenticated-orcid":true,"given":"Shitao","family":"Lian","sequence":"first","affiliation":[{"name":"School of Engineering Medicine, Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Interdisciplinary Innovation Institute of Medicine and Engineering, Beihang University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3613-2174","authenticated-orcid":true,"given":"Yadong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3966-3111","authenticated-orcid":true,"given":"Songnian","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second Affiliated Hospital of Dalian Medical University","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinping","family":"Ma","sequence":"additional","affiliation":[{"name":"CapitalBio Technology","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5527-143X","authenticated-orcid":false,"given":"Peng","family":"Yin","sequence":"additional","affiliation":[{"name":"School of Engineering Medicine, Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Interdisciplinary Innovation Institute of Medicine and Engineering, Beihang University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7111-7770","authenticated-orcid":false,"given":"Zilong","family":"He","sequence":"additional","affiliation":[{"name":"School of Engineering Medicine, Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Interdisciplinary Innovation Institute of Medicine and Engineering, Beihang University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.UTI-0017-2013"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.4.4.331-353.1919"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/146.6.719"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00019-07"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2003.04239.x"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2010.32"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.5.1989-1994.1994"},{"key":"e_1_3_4_9_2","first-page":"313","volume-title":"Pocket companion to Brenner and Rector\u2019s the kidney","author":"Clarkson MR","year":"2005","unstructured":"Clarkson MR, Magee CN, Brenner BM, eds. 2005. 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