{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:34:50Z","timestamp":1792715690823,"version":"4.5.0"},"reference-count":73,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1C1C1003379"],"award-info":[{"award-number":["2020R1C1C1003379"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008783","name":"National Research Council of Science and Technology","doi-asserted-by":"publisher","award":["CRC-16-01-KRICT"],"award-info":[{"award-number":["CRC-16-01-KRICT"]}],"id":[{"id":"10.13039\/501100008783","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003705","name":"Korea Institute of Toxicology","doi-asserted-by":"publisher","award":["1711133844"],"award-info":[{"award-number":["1711133844"]}],"id":[{"id":"10.13039\/501100003705","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"crossref","award":["6-2021-0155"],"award-info":[{"award-number":["6-2021-0155"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"crossref","award":["HV21C0050"],"award-info":[{"award-number":["HV21C0050"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2021R1C1C1006912"],"award-info":[{"award-number":["2021R1C1C1006912"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2022,6,29]]},"abstract":"<jats:p>Recent studies reported neurological and cognitive sequelae in patients with COVID-19\u2009months after the viral infection with several symptoms, including ageusia, anosmia, asthenia, headache, and brain fog. Our conclusions raise awareness of COVID-19-related microglia-mediated neurological disorders to develop treatment strategies for the affected patients.<\/jats:p>","DOI":"10.1128\/spectrum.01091-22","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T13:00:56Z","timestamp":1651755656000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":119,"title":["SARS-CoV-2 Infection of Microglia Elicits Proinflammatory Activation and Apoptotic Cell Death"],"prefix":"10.1128","volume":"10","author":[{"given":"Gi Uk","family":"Jeong","sequence":"first","affiliation":[{"name":"Center for Convergent Research for Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaemyun","family":"Lyu","sequence":"additional","affiliation":[{"name":"Arontier Co., Ltd., Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyun-Do","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Convergent Research for Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Cheul","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gun Young","family":"Yoon","sequence":"additional","affiliation":[{"name":"Center for Convergent Research for Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumin","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Convergent Research for Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Insu","family":"Hwang","sequence":"additional","affiliation":[{"name":"Center for Convergent Research for Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Ho","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsu","family":"Ko","sequence":"additional","affiliation":[{"name":"Arontier Co., Ltd., Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June-Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, College of Medicine, Yonsei University, Seoul, Republic of Korea"},{"name":"Institute for Immunology and Immunological Disease, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1100-5168","authenticated-orcid":true,"given":"Young-Chan","family":"Kwon","sequence":"additional","affiliation":[{"name":"Center for Convergent Research for Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-00468-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-00459-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200581"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30287-X"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.2125"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02166-2"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22809"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa330"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020201187"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-020-0786-5"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1091"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30161-2"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2008597"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2009787"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1127"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2038"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1114852"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-0297-1"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20265"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.08.031"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro.2002.13.3.221"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.67.7_suppl_2.s8"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3233\/jad-2006-9s330"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2006.40"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30308-2"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(20)30144-0"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-01024-2"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20202135"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00758-5"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108175"},{"key":"e_1_3_3_32_2","doi-asserted-by":"crossref","unstructured":"Bengsch B Schwabenland M Sali\u00e9 H Tanevski J Killmer S Matschke J P\u00fcschel K Mei H Boettler T Neumann-Haefelin C. 2020 Deep spatial profiling of COVID19 brains reveals neuroinflammation by compartmentalized local immune cell interactions and targets for intervention.","DOI":"10.21203\/rs.3.rs-63687\/v1"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2021.577728"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-020-04106-0"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.06.010"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3599"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00388"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401833"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400779"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11003"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.246"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.3390\/v9110316"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1579-0"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02645-3"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02012-06"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00737-08"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0778-2"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00405"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd2985"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2020.100127"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abf8396"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.06.002"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.628347"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00421"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10050509"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.706252"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042718-041417"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97229"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23844"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666180327170632"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1443-2"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4158-11.2011"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-016-0508-6"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0427-y"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900317"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-018-0297-x"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.327"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1435s104"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.14806\/ej.17.1.200"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw377"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.01091-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.01091-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T13:55:56Z","timestamp":1656510956000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.01091-22"}},"subtitle":[],"editor":[{"given":"Ujjwal","family":"Neogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,6,29]]},"references-count":73,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6,29]]}},"alternative-id":["10.1128\/spectrum.01091-22"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.01091-22","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,29]]},"assertion":[{"value":"2022-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01091-22"}}