{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:51:03Z","timestamp":1790736663805,"version":"4.1.0"},"reference-count":96,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Nagasaki University, Doctoral Program for World-leading Innovative and Smart Education \u201cWISE Program\u201d"},{"name":"Joint Research Center on Tropical Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2022,10,26]]},"abstract":"<jats:p>Disease manifestations of cutaneous leishmaniasis (CL) range from self-healing cutaneous lesions to chronic forms of the disease, depending on the infecting<jats:italic>Leishmania<\/jats:italic>sp. and host immune protection. Previous works on mouse models of CL show the distinct pathogenicity of<jats:named-content content-type=\"genus-species\">Leishmania major<\/jats:named-content>strains in the absence of lymphocytes.<\/jats:p>","DOI":"10.1128\/spectrum.01126-22","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T14:01:06Z","timestamp":1664805666000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Leishmania major Strain-Dependent Macrophage Activation Contributes to Pathogenicity in the Absence of Lymphocytes"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9416-7482","authenticated-orcid":false,"given":"Jalal","family":"Alshaweesh","sequence":"first","affiliation":[{"name":"Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan"},{"name":"Graduate School of Biomedical Sciences, Doctoral Leadership Program, Nagasaki University, Nagasaki, Japan"},{"name":"School of Tropical Medicine and Global Health, WISE Programme, Nagasaki University, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan"},{"name":"Graduate School of Biomedical Sciences, Doctoral Leadership Program, Nagasaki University, Nagasaki, Japan"},{"name":"The Joint Research Center on Tropical Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Hayashishita","sequence":"additional","affiliation":[{"name":"School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abu","family":"Musa","sequence":"additional","affiliation":[{"name":"Dana-Farber Cancer Institute, Harvard Medical University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihoko","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"The Joint Research Center on Tropical Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan"},{"name":"Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9791-927X","authenticated-orcid":true,"given":"Daniel Ken","family":"Inaoka","sequence":"additional","affiliation":[{"name":"School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan"},{"name":"Department of Molecular Infection Dynamics, Shionogi Global Infectious Disease Division, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3881-8337","authenticated-orcid":true,"given":"Shinjiro","family":"Hamano","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan"},{"name":"Graduate School of Biomedical Sciences, Doctoral Leadership Program, Nagasaki University, Nagasaki, Japan"},{"name":"The Joint Research Center on Tropical Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004349"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31204-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2021.105203"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(02)90044-1"},{"key":"e_1_3_3_6_2","unstructured":"WHO. 2022. Leishmaniasis. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/leishmaniasis. Accessed 2 January 2022."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4314\/thrb.v15i1.5"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.92682"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40794-019-0092-x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1179\/000349803225002516"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-75"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12556"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.72"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri933"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00626.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.122945.111"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70209-8"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007865"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2007.02.007"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb03719.x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.4049\/jimmunol.158.11.5374","article-title":"Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection","volume":"158","author":"Soong L","year":"1997","unstructured":"Soong L, Chang CH, Sun J, Longley BJ, Ruddle NH, Flavell RA, McMahon-Pratt D. 1997. Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection. J Immunol 158:5374\u20135383.","journal-title":"J Immunol"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1017\/S003118201600024X"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00432.x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12679"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.02.002"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(03)00047-3"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbs.2016.02.015"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.008"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59643"},{"key":"e_1_3_3_30_2","first-page":"73","volume-title":"Cellular and molecular immunology","author":"Abbas AK","year":"2021","unstructured":"Abbas AK, Lichtman AH, Pillai S. 2021. Innate immunity, p 73. In Cellular and molecular immunology, 10th ed. Elsevier Saunders, Philadelphia.","edition":"10"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.62.3.349"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145342"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2018.03.001"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.5564\/mjas.v15i2.544"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8367726"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009693"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.649348"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2016.02.003"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201546015"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.12.012"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0706440"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15367"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.04.040"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20155"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110919"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004300100084"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.8.4177-4184.2002"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-277202"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0713598"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3742"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01593"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00017"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031466"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12074"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.10.005"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.706510"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00262"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.12.7215-7218.2003"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.8.4237"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00155.2010"},{"key":"e_1_3_3_61_2","first-page":"124","article-title":"MyD88 is involved in myeloid as well as lymphoid hematopoiesis independent of the presence of a pathogen","volume":"3","author":"Fiedler K","year":"2013","unstructured":"Fiedler K, Kokai E, Bresch S, Brunner C. 2013. MyD88 is involved in myeloid as well as lymphoid hematopoiesis independent of the presence of a pathogen. Am J Blood Res 3:124\u2013140.","journal-title":"Am J Blood Res"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510802103"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05287.x"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2005.02122.x"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080743"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yadr.2008.09.004"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073143"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1391"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12312"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00528-16"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.12.005"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324128"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2009.09.017"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.160257897"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3100807"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.05.012"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.56720"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1006\/expr.2001.4656"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1902s28"},{"key":"e_1_3_3_80_2","unstructured":"Becton Dickinson and Company. 2021. FlowJo\u2122 software for windows pWindows."},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015263"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.3791\/57486"},{"key":"e_1_3_3_83_2","unstructured":"Andrews S. 2010. FASTQC: A quality control tool for high throughput sequence data. https:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/."},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3519"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3252"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4324"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.97"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4"},{"key":"e_1_3_3_90_2","unstructured":"Kolde R. 2019. pheatmap: Pretty heatmaps. R package version 1.0.12. https:\/\/cran.r-project.org\/web\/packages\/pheatmap\/."},{"key":"e_1_3_3_91_2","unstructured":"Blighe K Rana S Lewis M. 2021. EnhancedVolcano: Publication-ready volcano plots with enhanced colouring and labeling. R package version 1.11.3. https:\/\/github.com\/kevinblighe\/EnhancedVolcano."},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1007664"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100141"},{"key":"e_1_3_3_96_2","unstructured":"Yu G. 2021. enrichplot: Visualization of Functional Enrichment Result. R package version 1.15.3. https:\/\/yulab-smu.top\/biomedical-knowledge-mining-book\/."},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt285"}],"container-title":["Microbiology Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.01126-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/spectrum.01126-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T19:12:42Z","timestamp":1677006762000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/spectrum.01126-22"}},"subtitle":[],"editor":[{"given":"Tiffany","family":"Weinkopff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":96,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10,26]]}},"alternative-id":["10.1128\/spectrum.01126-22"],"URL":"https:\/\/doi.org\/10.1128\/spectrum.01126-22","relation":{},"ISSN":["2165-0497"],"issn-type":[{"value":"2165-0497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,26]]},"assertion":[{"value":"2022-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01126-22"}}