{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:05:10Z","timestamp":1785434710336,"version":"3.56.0"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Severe fever with thrombocytopenia syndrome (SFTS), a life-threatening\n                        tick-borne zoonosis caused by severe fever with thrombocytopenia syndrome\n                        virus (SFTSV), frequently leads to fatal encephalitis characterized by\n                        consciousness disorders and seizures. The molecular mechanisms governing\n                        SFTSV neuroinvasion and host-driven neural injury remain largely elusive. To\n                        explore the mechanisms of SFTS-induced brain damage, we analyzed clinical\n                        laboratory parameters and conducted transcriptomic analyses of peripheral\n                        blood mononuclear cells from five SFTS patients with encephalitis and five\n                        non-encephalitis patients admitted to Nanjing Drum Tower Hospital during the\n                        same period. Our findings indicate that central nervous system\n                        manifestations in SFTSV infection are associated with altered expression of\n                        immune-related genes. Specifically, we identified six differentially\n                        expressed immune genes\u2014MET, KIT, IL1R2, MAFF, CD69, and\n                        CEBPD\u2014between the encephalitis and non-encephalitis groups. This\n                        study provides novel insights into the pathogenesis of SFTS-associated\n                        encephalitis, and further investigation into the host immune response\n                        post-SFTSV infection may aid in mitigating disease progression and improving\n                        clinical outcomes.<\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening\n                            disease that can lead to encephalitis\u2014a serious brain\n                            inflammation with high mortality. However, the causes of this brain\n                            damage remain largely unknown. In this study, we used advanced gene\n                            sequencing techniques to analyze blood samples from SFTS patients with\n                            and without encephalitis. Our results revealed key changes in\n                            immune-related genes, uncovering possible biological pathways involved\n                            in brain injury caused by the virus. These findings shed new light on\n                            how the immune system may contribute to neurological complications in\n                            SFTS and highlight specific genes that could serve as future targets for\n                            diagnosis or treatment. This research enhances our understanding of\n                            SFTS-related encephalitis and provides a valuable foundation for\n                            developing therapies to improve patient outcomes.<\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.01161-25","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:00:13Z","timestamp":1758632413000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Blood transcriptomic profiling reveals gene expression alterations in                    patients with SFTS-associated encephalitis"],"prefix":"10.1128","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3403-8258","authenticated-orcid":false,"given":"DaiQing","family":"Wu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01rxvg760","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Clinical Laboratory, Nanjing Drum Tower Hospital, Clinical College of Jiangsu University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AoFan","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01rxvg760","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Clinical Laboratory, Nanjing Drum Tower Hospital, Clinical College of Jiangsu University","place":["Nanjing, 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