{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:18:37Z","timestamp":1785421117562,"version":"3.56.0"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Microbiol Spectr"],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      This study aimed to investigate the epidemic status and distribution characteristics of drug-resistant\n                      <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                      in Urumqi. From January 2019 to July 2024, all sputum culture-positive\n                      <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                      strains were collected in Urumqi. Using the traditional solid-state proportion method for drug-sensitivity testing, we determined the resistance of\n                      <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                      to first-line antituberculosis (TB) drugs. The epidemic status and distribution characteristics of first-line antituberculosis drug-resistant\n                      <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                      were analyzed using R statistical software (version 3.6.1). Among the 1,241 culture-positive\n                      <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                      strains included in this analysis, 973 (78.40%) were smear positive. The overall proportion of non-tuberculous mycobacteria was 2.5%. The overall prevalence of drug-resistant tuberculosis (DR-TB) was 18.93%, with a prevalence of 17.78% in new cases and 24.40% in retreatment cases, respectively. In this survey, the overall prevalence was 10.91% (132 out of 1,210) for mono-drug-resistant tuberculosis, 3.72% (45 out of 1,210) for polydrug-resistant tuberculosis, and 4.30% (52 out of 1,210) for multidrug-resistant tuberculosis. Moreover, the patterns of resistance to first-line anti-TB drugs were highly diverse. The drug-resistance rate among retreatment tuberculosis patients in Urumqi remains notably high. Thus, enhancing drug-resistance surveillance in these patients is critical for effective tuberculosis prevention and control in the region.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>IMPORTANCE<\/jats:title>\n                    <jats:p>The result of this study indicated that DR-TB is a serious public health problem in Urumqi. Resistance drugs distributed type to first-line anti-TB drugs are very broad in Urumqi. Any resistance to anti-TB drugs in new cases is more than in retreatment cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/spectrum.01370-25","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T13:00:09Z","timestamp":1756904409000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence and distribution patterns of drug resistance in\n                    <i>Mycobacterium tuberculosis<\/i>\n                    to first-line antituberculosis drugs in Urumqi, China"],"prefix":"10.1128","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5191-9370","authenticated-orcid":false,"given":"Jiandong","family":"Yang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02yr91f43","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Tuberculosis Control and Prevention, Urumqi Center for Disease Control and Prevention","place":["Urumqi, People\u2019s Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/01p455v08","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Public Health, Xinjiang Medical University","place":["Urumqi, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5939-0626","authenticated-orcid":false,"given":"Pengwei","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Big Data, College of Information Engineering, Xinjiang Institute of Engineering","place":["Urumqi, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weisheng","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02yr91f43","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Tuberculosis Control and Prevention, Urumqi Center for Disease Control and Prevention","place":["Urumqi, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanggui","family":"Chen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02yr91f43","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Tuberculosis Control and Prevention, Urumqi Center for Disease Control and Prevention","place":["Urumqi, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoqin","family":"Lu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02yr91f43","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Tuberculosis Control and Prevention, Urumqi Center for Disease Control and Prevention","place":["Urumqi, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control and Prevention, Urumqi Center for Disease Control and Prevention","place":["Urumqi, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peisheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Science, Education and International Exchange, Urumqi Center for Disease Control and Prevention","place":["Urumqi, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01p455v08","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Medical Engineering and Technology, Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijtb.2023.04.009"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.612675"},{"key":"e_1_3_5_4_2","unstructured":"World Health Organization. 2024. 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